Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T74570
|
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| Former ID |
TTDI03315
|
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| Target Name |
Kir2.1
|
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| Gene Name |
KCNJ2
|
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| Synonyms |
KCNJ2
|
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| Target Type |
Research
|
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| UniProt ID | |||||
| Sequence |
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFIN
VGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGK ACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVM AKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEG EYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEG MVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARD LAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRP LRRESEI |
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| Inhibitor (gating inhibitor) | oleoyl-CoA | Drug Info | [1] | ||
| Activator | PIP2 | Drug Info | [2] | ||
| References | |||||
| REF 1 | Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels. J Physiol. 2006 Sep 1;575(Pt 2):433-42. Epub 2006 Jun 15. | ||||
| REF 2 | Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels. FEBS Lett. 2001 Feb 9;490(1-2):49-53. | ||||
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