Drug General Information
Drug ID
D07ZAJ
Former ID
DIB020727
Drug Name
PIP2
Synonyms
PIP2; PIP2; phosphatidylinositol-4,5-bisphosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539517]
Structure
Download
2D MOL
Formula
C45H85O19P3
InChI
InChI=1S/C45H85O19P3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(46)59-35-37(61-39(47)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)36-60-67(57,58)64-43-40(48)41(49)44(62-65(51,52)53)45(42(43)50)63-66(54,55)56/h17-20,37,40-45,48-50H,3-16,21-36H2,1-2H3,(H,57,58)(H2,51,52,53)(H2,54,55,56)/b19-17-,20-18-/t37-,40-,41+,42+,43-,44-,45-/m1/s1
InChIKey
IGQSAMXNWMLOOS-GGDMTQDZSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Kir3.2 Target Info Activator [534567]
Potassium channel KCNJ3 Kir3.1 Target Info Activator [534567]
Kir3.3 Target Info Activator [534143]
Potassium voltage-gated channel subfamily KQT member 4 Target Info Activator [527827]
TRPM7 Target Info Activator [526311]
IP3R1 Target Info Antagonist [543955]
PLD2 Target Info Activator [534622]
Kir2.1 Target Info Activator [525964]
ATP-sensitive K+ channel Target Info Activator [534737]
HCN2 Target Info Activator [528505]
TRPM4 Target Info Activator [527762]
Potassium voltage-gated channel subfamily KQT member 2 Target Info Activator [527827]
KEGG Pathway Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Estrogen signaling pathway
Oxytocin signaling pathway
Morphine addictionhsa04725:Cholinergic synapsehsa04713:Circadian entrainment
Morphine addictionhsa04725:Cholinergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
GABA-B receptor II signalingP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Muscle/Heart ContractionPW000564:Muscle/Heart Contraction
Reactome Activation of G protein gated Potassium channels
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsR-HSA-1296072:Voltage gated Potassium channelsR-HSA-1296041:Activation of G protein gated Potassium channels
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsR-HSA-1296072:Voltage gated Potassium channels
Interaction between L1 and Ankyrins
WikiPathways Calcium Regulation in the Cardiac Cell
G Protein Signaling Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium ChannelsWP2669:Potassium ChannelsWP536:Calcium Regulation in the Cardiac Cell
Notch Signaling Pathway
Potassium ChannelsWP2669:Potassium Channels
L1CAM interactions
References
Ref 539517(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2387).
Ref 525964Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels. FEBS Lett. 2001 Feb 9;490(1-2):49-53.
Ref 526311The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol. 2002 May;4(5):329-36.
Ref 527762Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization. J Biol Chem. 2005 Nov 25;280(47):39185-92. Epub 2005 Sep 26.
Ref 527827Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate. J Neurosci. 2005 Oct 26;25(43):9825-35.
Ref 528505Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. J Gen Physiol. 2006 Nov;128(5):593-604.
Ref 534143Regulation of cardiac Na+,Ca2+ exchange and KATP potassium channels by PIP2. Science. 1996 Aug 16;273(5277):956-9.
Ref 534567Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature. 1998 Feb 19;391(6669):803-6.
Ref 534622Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. J Biol Chem. 1998 May 22;273(21):12846-52.
Ref 534737PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science. 1998 Nov 6;282(5391):1141-4.
Ref 543955(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 743).

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