Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 15-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| MMP2 --- MMP9 | 5-(4-Phenoxyphenyl)-5-(4-(3,5-diethoxybenzoyl)-1,4-diazepan-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | Cyanoguanidine derivative | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-N-(4-(4-(methylsulfonyl)piperazin-1-yl)-1-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)butan-2-yl)formamide | Drug Info |
| Ftase --- FPTase | 2-(2-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| MMP2 --- MMP9 | N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)-N-methyl-4-(4-(trifluoromethoxy)phenoxy)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 4-chloro-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(3-((4-(4-Chlorophenoxy)benzamido)methyl)-4-methoxybenzyl)butanoic acid | Drug Info |
| MMP2 --- MMP9 | 1-hydroxy-3-(4-(4-methoxyphenoxy)phenylsulfonyl)azepan-2-one | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-3-yl-ethanone | Drug Info |
| PPAR gamma --- PPAR delta | 2-Ethylsulfanyl-3-[4-methoxy-3-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-propionic acid | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-4-(1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid | Drug Info |
| Ftase --- FPTase | N-Furan-3-ylmethyl-N-isopropyl-2-(2-phenyl-1H-indol-3-yl)-acetamide | Drug Info |
| PR --- mRNA of AR | 4'-methoxy-3-trifluoromethyl-biphenyl-4-carbonitrile | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-(4-phenylazo-benzenesulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | (2-Benzylamino-phenyl)-[1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-methanone | Drug Info |
| PR --- mRNA of AR | 4-(5-fluoro-2-hydroxyphenyl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-1H-benzo[d][1,2]oxazin-6-yl)-2-(trifluoromethyl)pentanamide | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-methyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylmethyl-amide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| PR --- mRNA of AR | 7-Ethyl-6-methyl-4-trifluoromethyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one | Drug Info |
| MMP3 --- MMP8 | {2-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 7-Bromo-3-(2-chloro-benzyl)-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| PR --- mRNA of AR | 4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-1H-benzo[d][1,2]oxazin-6-yl)-2-(trifluoromethyl)pentanamide | Drug Info |
| MMP3 --- MMP8 | [(R)-6-Amino-2-(4'-fluoro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid phenylamide | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(4-cyclohexylphenyl)-3-(3-fluorophenyl)propan-1-one | Drug Info |
| MMP9 --- MMP3 | (R)-2-((S)-2-Hydroxy-3-mercapto-propyl)-nonanoic acid [(S)-1-(2-ethylamino-4-methyl-pentanoylaminocarbonyl)-3-methyl-butyl]-amide | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(3,4-Dichloro-benzyloxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-3-(thiophen-3-yl)-1-p-tolylpropan-1-one | Drug Info |
| mTOR --- AKT | N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide | Drug Info |
| Ftase --- FPTase | 6-[3-(4-cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| PR --- mRNA of AR | 1,6,8,8,10-Pentamethyl-4-trifluoromethyl-6,7,8,9-tetrahydro-1H-pyrido[3,2-g]quinolin-2-one | Drug Info |
| mTOR --- DNPK1 | 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzyl ester | Drug Info |
| Renin --- Cathepsin D | {1-[1-[1-Cyclohexylmethyl-2-(1-cyclohexyl-2-oxo-pyrrolidin-3-yl)-2-hydroxy-ethylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| mTOR --- PI3K gamma | 2-(N-Methylindol-3-ylmethylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 5-[(4-Cyano-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2'-methyl-biphenyl-2-carbonitrile | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid benzyl ester | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(3-Isopropyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-(4-morpholin-4-ylphenyl)urea | Drug Info |
| Ftase --- FPTase | 2-(1-Benzenesulfonyl-piperidin-4-yl)-1-[4-((R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid m-tolylamide | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-1-methyl-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| Ftase --- FPTase | 6-[(4'-Chloro-6-cyano-biphenyl-3-yl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-1-methyl-2-oxo-5-(4-trifluoromethoxy-phenyl)-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| S5AR --- SRD5A2 | (5S,10R,13S,17S)-10,13-Dimethyl-3-nitro-2,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-carboxylic acid diisopropylamide | Drug Info |
| mTOR --- PI3K gamma | N-[2-(Dimethylamino)ethyl]-4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}aminobenzamide | Drug Info |
| Ftase --- FPTase | 2-[2-(2-Chloro-phenyl)-1H-indol-3-yl]-N-(2-cyano-ethyl)-N-cyclopropyl-acetamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-9a,11a-dimethyl-1-(piperidine-1-carbonyl)-3,3a,3b,4,5,8,9,9a,9b,10,11,11a-dodecahydro-1H-cyclopenta[i]phenanthridin-7(2H)-one | Drug Info |
| NET --- SERT | 3N-{7-[4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinylcarboxamido]heptyl}-4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinecarboxamide | Drug Info |
| Ftase --- FPTase | 4-{5-[(2-Oxo-3-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| S5AR --- SRD5A2 | 17-tert-Butylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
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