Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | (13S,17S)-2-Hydroxymethyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
| MMP13 --- MMP1 | (3S,6S)-6-(2-amino-2-oxoethyl)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (3R,8S,9S,10R,13S,14S,17S)-17-(diisopropylcarbamoyl)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-3-propylphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| MMP13 --- MMP1 | 4-(4-But-2-ynyloxy-benzenesulfonyl)-1-(pyridine-3-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 4-(4-Chloro-5-methoxy-2-methyl-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 3,7,8-trihydroxy-4-methyl-6H-benzo[c]chromen-6-one | Drug Info |
| MMP13 --- MMP14 | N-((2S,4S)-1-(4-(2,4-dichlorobenzyloxy)piperidin-1-ylsulfonyl)-4-(5-fluoropyrimidin-2-yl)-2-methylpentan-2-yl)-N-hydroxyformamide | Drug Info |
| ABL --- Src | 4-(2-Chloro-5-methoxy-phenylamino)-6-methoxy-7-(1-methyl-piperidin-4-ylmethoxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | (2R,3R,4S)-3-(4-Hydroxy-phenyl)-4-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-chroman-7-ol | Drug Info |
| MMP13 --- MMP9 | 5-Bromo-4-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-thiophene-3-carboxylic acid hydroxyamide | Drug Info |
| PDGFR --- Src | 8-Methyl-2-phenylamino-6-thiophen-3-yl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-7-(3-(piperidin-1-yl)propoxy)-1H-indol-3-yl)acetamide | Drug Info |
| MMP2 --- HER2 | (2S,3S)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-((R)-3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID50085782 | Drug Info |
| Erbeta --- ER | 2-(2-Fluoro-4-hydroxy-phenyl)-7-propenyl-benzooxazol-5-ol | Drug Info |
| MMP2 --- MMP1 | 2-(R)-1-Hydrazinocarbonylmethyl-4-methyl-pentanoic acid [2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-4-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)butan-1-one | Drug Info |
| Erbeta --- Mcl1 | SID860234 | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-2-(N-isopentyl-6-methoxynaphthalene-2-sulfonamido)-3-methylbutanamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(benzo[b]thiophen-3-ylmethyl)-2-(4-sulfamoylphenylamino)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-{[1-((R)-2-Amino-3-mercapto-propionyl)-4-phenyl-piperidine-4-carbonyl]-amino}-4-methyl-pentanoic acid | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-4-(4-(4-(4-isopropylpiperazine-1-carbonyl)piperidin-1-yl)phenylsulfonyl)tetrahydro-2H-pyran-4-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-(methylsulfonyl)phenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxylic acid | Drug Info |
| Ftase --- FPTase | 8-Chloro-11-(1-ethenesulfonyl-piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | Drug Info |
| MMP2 --- MMP13 | 2-Dimethylamino-N-hydroxy-2-methyl-3-(4-phenoxy-benzenesulfonyl)-propionamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4'-(trifluoromethyl)biphenyl-4-carbonitrile | Drug Info |
| Ftase --- FPTase | 17-oxo-16-(2-thienylmethyl)-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| MMP2 --- MMP13 | (S)-N-(3,4-dimethoxybenzyl)-4-(4-((3-hydroxyquinuclidin-3-yl)ethynyl)phenoxy)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Methyl-1-(indol-3-yl)-2-acetyl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| Ftase --- FPTase | {2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(5-Acetyl-4-hydroxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[4-(2,2-difluoro-1,3-benzodioxol-5-yl)phenyl]sulfamide | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[Benzyl-(1H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| MMP2 --- MMP13 | 2-(4'-Methoxy-biphenyl-4-sulfonylamino)-6-pyrrolidin-1-yl-hex-4-ynoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-methyl-4-phenyl-1,2,3,4,8,9-hexahydrofuro[2,3-h]isoquinoline | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-(1-methyl-2-o-tolyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| MMP2 --- MMP3 | (R)-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-N*4*-hydroxy-2-[3-(2-trifluoromethyl-biphenyl-4-yl)-propyl]-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-cyclopropyl-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2H-pyrrol-1(5H)-yl)-2-hydroxyethanone | Drug Info |
| Ftase --- FPTase | [1-(3-Benzo[1,3]dioxol-5-ylmethyl-3H-imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-morpholin-4-yl-methanone | Drug Info |
| MMP2 --- MMP3 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[(S)-2-((S)-3-methyl-1-phenylcarbamoyl-butylcarbamoyl)-4-phenyl-butyl]-phosphinic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-amino-3-((4-(methylthio)phenyl)diphenylmethylthio)propanoic acid | Drug Info |
| Ftase --- FPTase | 1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrole-3-carboxylic acid ethyl ester | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-6-(3',5'-dichloro-biphenyl-4-yl)-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-hydroxy-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,7-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP3 | (2R,3S)-N*4*-[(S)-1-(Benzhydryl-carbamoyl)-2,2-dimethyl-propyl]-2,N*1*-dihydroxy-3-(3-phenyl-propyl)-succinamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)propyl)-4-methoxycyclohexanecarboxamide | Drug Info |
| Ftase --- FPTase | [((2E,6E,10E)-3,7,11,15-Tetramethyl-hexadeca-2,6,10,14-tetraenylcarbamoyl)-methyl]-phosphonic acid | Drug Info |
| MMP-2 --- MMP-3 | (R)-1-(1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-3-(5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)urea | Drug Info |
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