Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| 5HT1a --- SERT | 1-(biphenyl-4-yl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-chlorophenyl)piperazin-1-yl)-1-phenylpropan-1-ol | Drug Info |
| 5LOX --- HRH1 | [4-((2S,5S)-5-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-ylmethyl}-tetrahydro-furan-2-yl)-but-3-ynyl]-N-hydroxyurea | Drug Info |
| AChE --- NMDA | CHEMBL50608 | Drug Info |
| ADRA1A --- HRH1 | (8-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | Drug Info |
| ADRA1A --- HRH1 | 3-{4-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-butyl}-1H-indole-5-carboxylic acid amide | Drug Info |
| ADRA1A --- HRH1 | SID170465934 | Drug Info |
| CABL --- FGFR1 | PHA848125 | Drug Info |
| CABL --- VEGFR1 | compound 8h | Drug Info |
| Aurora --- GSK | 4-(5-nitro-4-(phenylamino)pyrimidin-2-ylamino)benzoic acid | Drug Info |
| AuroraA --- CDK4 | 7-cyclohexyl-N-4-4-2-methoxyethyl-piperazin-1-yl-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine | Drug Info |
| AuroraA --- STK1 | N-ethyl-2-(2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-phenylacetamide | Drug Info |
| AuroraA --- STK1 | 3-(((2S,6R)-2,6-dimethylmorpholino)methyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | 2-Methyl-2-[[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolyl]methyl](2,2,2-trifluoroethyl)amino]-1-propanol Hydrochloride | Drug Info |
| AuroraA --- STK1 | CHEMBL386253 | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | 6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(5-chloro-1H-benzo[d]imidazol-2-ylamino)phenethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | 4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)phthalazin-1-amine | Drug Info |
| Beta PDGFR --- CABL | 1-(3-(dimethylamino)phenyl)-3-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)urea | Drug Info |
| Beta PDGFR --- Ckit | 4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (6-trifluoromethyl-pyridin-3-ylmethyl)-amide | Drug Info |
| BNOS --- Hepatocyte NOS | 7-(2-Ethyl-butyl)-azepan-(2Z)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | SID50107209 | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(2-Pyrrolidin-1-yl-ethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(2-Dimethylamino-cyclohexyloxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-8-Chloro-6-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Benzyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl)ethyl)-N2-(benzo[d][1,3]dioxol-5-ylmethyl)-N2-methylethane-1,2-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(6-methylpyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-6,7-Difluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| CAI --- CAIX | SID144212483 | Drug Info |
| 5HT1a --- SERT | 4-{(S)-2-Hydroxy-3-[(2R,4R)-4-(4-methoxy-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-propoxy}-1H-indole-2-carboxylic acid amide | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(6-isopropoxy-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-[(2S,4S)-4-(4-Methoxy-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1b --- SERT | 2'-Methyl-4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-carboxylic acid [4-hydroxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide | Drug Info |
| 5LOX --- HRH1 | 1-(4-{4-[3-(4-{13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene}piperidin-1-yl)propoxy]phenyl}but-3-yn-1-yl)-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | 4-[(3,4-Difluorophenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | Dimethyl-[(2S,3aR)-1-(2,3,3a,8-tetrahydro-1-oxa-12b-aza-dibenzo[e,h]azulen-2-yl)methyl]-amine | Drug Info |
| ADRA1A --- HRH1 | Esmirtazapine | Drug Info |
| CABL --- CD135 | VX-680 | Drug Info |
| CABL --- FGFR1 | PHA-665752 | Drug Info |
| CAI --- CAIX | 2-cyclohexylamido-5-sulfonamidoindane | Drug Info |
| Aurora --- VEGFR | 7-(1H-indol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | (Z)-N-(3-{[3-(3-Morpholino-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]methylene}-2-oxoindolin-5-yl)benzenesulfonamide | Drug Info |
| AuroraA --- STK1 | (R)-N-(5-(2-fluoro-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide | Drug Info |
| AuroraA --- STK1 | 6-Methyl-3-(1H-pyrazol-4-yl)-N-[3-[(3,3,4,4-tetrafluoro-1-pyrrolidinyl)methyl]-5-isothiazolyl]imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | 3-methyl-N-(6-(morpholinomethyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(piperidin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | 4-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | (R)-1-(2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl)-N-phenylpiperidine-3-carboxamide | Drug Info |
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