Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| H3 --- SERT | N,N-diethyl-3-(6-methyl-8-phenyl-5,6,7,8-tetrahydro-2,6-naphthyridin-3-yloxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Bromo-4-fluoro-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-methyl 2-((R)-2-amino-3-(tritylthio)propanamido)-3-methylbutanoate | Drug Info |
| PI3K gamma --- PI3K delta | 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one | Drug Info |
| H3 --- SERT | 3-(4-methoxyphenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 4-[(2-Methoxy-ethyl)-methyl-amino]-but-2-enoic acid [4-(4-benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(1-(3-hydroxyphenyl)-6-(trifluoromethoxy)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-6-fluoro-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| H3 --- SERT | (2-(3,4-dichlorophenoxy)-5-(4-(4-fluoropiperidin-1-yl)but-1-ynyl)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | 5-(bis(2,5-dihydroxybenzyl)amino)-2-hydroxybenzoic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-6-Chloro-1-(indol-3-yl)-2-(beta-aminopropionyl)-1,2,3,4-tetrahydro-beta-carboline hydrochloride | Drug Info |
| PI3K gamma --- PI3K delta | 2-(4-(2-methyl-8-(2-(pyridin-3-yl)ethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile | Drug Info |
| HDAC --- VEGFR | N2-(2-aminophenyl)-N5-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)thiophene-2,5-dicarboxamide | Drug Info |
| EGFR3 --- HER2 | (E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl3-p-tolylacrylate | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)urea | Drug Info |
| PKCA --- NPKC delta | 4-(2-Acetoxymethoxycarbonyl-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-4-(4-hydroxy-benzoylamino)-pyrrolidin-3-yl ester | Drug Info |
| HDAC1 --- HD6 | 2-(N-Acetamido)-ethyl 2-(4-methoxyphenyl)-2-oxoethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | 2-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(trifluoromethyl)-9H-carbazole | Drug Info |
| PKCA --- NPKC delta | 3,5-Dihydroxy-4-(2-hydroxy-6-methanesulfonylamino-benzoyl)-benzoic acid (R)-2-((S)-4-hydroxy-benzoylamino)-cyclopentyl ester | Drug Info |
| HDAC1 --- HD6 | N1-(biphenyl-4-yl)-N8-hydroxyoctanediamide | Drug Info |
| EGFR3 --- HER2 | 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carbohydrazide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-((2R,4aS,5R,10bS)-9-tert-butyl-5-(thiophen-2-yl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)-N-methylmethanamine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (3R,4R)-3-(4-hydroxy-benzoylamino)-piperidin-4-yl ester | Drug Info |
| HDAC1 --- HD6 | N-(1-(naphthalen-1-yl)ethyl)-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-(4-((cyclopropylamino)methyl)styryl)-6-methylpyrimidin-4-amine | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829429 | Drug Info |
| PPAR gamma --- 5LOX | (R)-2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)-2-(naphthalen-1-yl)acetic acid | Drug Info |
| HDAC1 --- HD6 | (S)-3-chlorobenzyl 1-oxo-1-(4-phenylthiazol-2-ylamino)-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Chloro-4-fluoro-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | rac-3-(4-hydroxyphenyl)-2-methyl-6-(piperidin-1-yl)-2,3-dihydroquinazolin-4(1H)-one | Drug Info |
| PPAR gamma --- PPAR delta | (S)-3-(4-(3,3-bis(4-bromophenyl)allyloxy)phenyl)-2-ethoxypropanoic acid | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(4-phenylthiazol-2-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| EGFR3 --- MCSF | (4-Chloro-phenyl)-(6,7-dimethoxy-quinazolin-4-yl)-methyl-amine; hydrochloride | Drug Info |
| TRIP5 --- mRNA of KIF11 | CHEMBL1829424 | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-benzoylamino)-methyl]-4-ethoxy-2-fluoro-benzyl}-butyric acid | Drug Info |
| HDAC1 --- HDAC2 | 1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one | Drug Info |
| Erbeta --- ER | (4-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[2-(4-hydroxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-piperazin-1-yl)-(4-methoxy-phenyl)-methanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(3-Hydroxyphenyl)-3-carboxy-1,2,3,4-tetrahydro-beta-carboline-3-(N-(2-aminoethyl))formamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-methyl-2-(2-methyl-4-((1-methyl-5-(4-(pyrrolidin-1-yl)phenyl)-1H-pyrazole-3-carboxamido)methyl)phenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 8-(Biphenyl-4-sulfonyl)-2-oxo-octanoic acid methylamide | Drug Info |
| Erbeta --- ER | (6-Hydroxy-2-phenyl-3,4-dihydro-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| Lck --- VEGFR | 5,6-diphenyl-N-(2-(piperazin-1-yl)ethyl)furo[2,3-d]pyrimidin-4-amine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-6-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(4-aminobiphenyl-3-yl)nicotinamide | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-7-methyl-benzofuran-5-ol | Drug Info |
| Src --- VEGFR | CHEMBL436968 | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-ethoxy-3-(4-(3-(4-phenoxyphenoxy)propoxy)phenyl)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-(3-(4-sec-Butoxy-3-methoxyphenyl)propanamido)-N-hydroxybenzamide | Drug Info |
| Erbeta --- ER | (13S,17S)-4-(3-Hydroxy-propyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
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