Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| MMP2 --- MMP9 | N-hydroxy-N-(1-((R)-tetrahydrofuran-2-yl)-2-(4-(4-(trifluoromethoxy)phenoxy)phenylsulfonyl)ethyl)formamide | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(2-hydroxyethyl)phenylamino)-4-(thiophen-2-yl)pyrimidine-5-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-Acetyl-3-benzyl-1-(3H-imidazol-4-ylmethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-p-tolylethynyl-phenylsulfanyl)-butyric acid | Drug Info |
| VEGFR2 --- Ckit | 6,6-Dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 2-{[1-(Benzyl-thiazol-5-ylmethyl-carbamoyl)-5-o-tolyl-1,2,3,6-tetrahydro-pyridine-4-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| MMP3 --- MMP8 | [2-(2-Biphenyl-4-yl-ethanesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid | Drug Info |
| VEGFR2 --- Cmet | N-(4-(2-(3-acetylphenyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Ftase --- FPTase | [4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-imidazol-1-yl-methanone | Drug Info |
| MMP3 --- MMP8 | 2-(Naphthalene-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(1-methyl-1H-pyrrol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-[1-(1-oxy-pyridine-4-carbonyl)-piperidin-4-yl]-ethanone | Drug Info |
| MMP3 --- MMP8 | Sodium; 3-[3-hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl]-propionate | Drug Info |
| VEGFR2 --- CSrc | 2-((3,5-dimethoxy)-4-((2-(4-methyl-1-piperazinyl)ethyl)oxy)phenyl)amino)-6-(2,6-dimethylphenyl)pyrimido-[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | [(S)-2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-1-(4-methoxy-benzylsulfanylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester | Drug Info |
| GPR109A --- MOGAT2 | Nicotinamide | Drug Info |
| VEGFR2 --- CSrc | N-(3-(1-(6-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(1-methylpiperidin-4-yloxy)-5-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-methyl-amino}-pentanoylamino)-4-hydroxy-butyric acid | Drug Info |
| mTOR --- AKT | trans-2-amino-8-((1r,4r)-4-hydroxycyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpteridin-7(8H)-one | Drug Info |
| VEGFR2 --- CSrc | 6-(2,6-dichlorophenyl)-2-((4-(4-methyl-1-piperazinyl)phenyl)amino)-pyrimido[5',4':5,6]pyrimido[1,2-a]-benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-chloro-benzyl ester | Drug Info |
| mTOR --- PI3K gamma | 4,6-dihydroxy-2-((5-methoxy-2-(pyridin-3-yl)-1H-indol-3-yl)methylene)benzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- CSrc | (5-Chloro-benzofuran-4-yl)-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3-phenyl-propionyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| mTOR --- PI3K gamma | (S)-1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-N-[4-({4-[(3-chlorobenzyl)oxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)-7-ethoxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclopentylamide 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| mTOR --- PI3K gamma | 4-(3-(4-(3-ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)ureido)benzamide | Drug Info |
| VEGFR2 --- FGFR1 | 3-(3,5-Dimethoxy-phenyl)-N*7*-[3-(4-methyl-piperazin-1-yl)-propyl]-[1,6]naphthyridine-2,7-diamine | Drug Info |
| Ftase --- FPTase | 2-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-9-(3-chloro-phenyl)-5-methyl-5,9-dihydro-8-thia-5-aza-benzocyclohepten-6-one | Drug Info |
| mTOR --- PI3K gamma | isopropyl 4-[6-(4-{[(2-fluoroethyl)carbamoyl]amino}phenyl)-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate | Drug Info |
| VEGFR2 --- TEK | N-(6-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)benzthiazol-2-yl)methanesulfonamide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid 1-methyl-piperidin-4-yl ester | Drug Info |
| NET --- SERT | SID533836 | Drug Info |
| VEGFR2 --- TEK | 7-Cyclopentyl-6-methyl-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| Ftase --- FPTase | 2-[1-(3-Bromo-benzyl)-1H-indol-3-yl]-N-isopropyl-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| NET --- SERT | 1-[3-(4-Isopropenyl-phenyl)-8-aza-bicyclo[3.2.1]oct-2-yl]-propan-1-one | Drug Info |
| VEGFR2 --- TEK | 3-isopropyl-N-(3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-naphthalen-1-ylmethyl-amino}-acetylamino)-4-hydroxy-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(piperidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)benzamide | Drug Info |
| Ftase --- FPTase | 1-[3-Benzyl-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)acrylamide | Drug Info |
| VEGFR2 --- TEK | 1-(4-(4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl)phenyl)-3-(2-fluoro-6-(trifluoromethyl)phenyl)urea | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-4-yl-ethanone | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(2-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | isopropyl 5-methyl-3-oxo-9-propyl-2,3,5,7,8,9-hexahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-12-ylcarbamate | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-benzyl-amino}-3-phenyl-propionylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(3-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 4-fluoro-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
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