Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| AuroraA --- STK1 | (S)-4-(2-amino-6-(3-amino-1H-indazol-6-yl)pyrimidin-4-yl)-N-phenylmorpholine-2-carboxamide | Drug Info |
| AuroraA --- STK1 | Deuterated 6-Methyl-3-(1H-pyrazol-4-tl)-N-[3-[[(3,3,3-trifluoropropyl)amino]methyl-(d2)]-5-isothiazolyl]imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | 3-((2,2-dimethylpiperidin-1-yl)methyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | 4-methyl-N-(3-(2-(5-(methylsulfonamido)-6-(pyrrolidin-1-yl)-1H-indazol-3-yl)vinyl)phenyl)piperazine-1-carboxamide | Drug Info |
| CDK1 --- Cyclin E | R-roscovitine | Drug Info |
| Beta PDGFR --- Ckit | 4-[6-Methoxy-7-(2-pyrrolidin-1-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (furan-2-ylmethyl)-amide | Drug Info |
| BNOS --- Hepatocyte NOS | 2-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl)-N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)pyrrolidine-1-carboxamide | Drug Info |
| BNOS --- Hepatocyte NOS | 6-{7-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-indan-4-yl}-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Amino-3-(2-guanidino-phenyl)-propionic acid | Drug Info |
| BNOS --- Hepatocyte NOS | 5,6-Dimethyl-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | SID124880731 | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Imino-3-methyl-2-pentyl-pyrrolidinium; chloride | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Aminomethyl-phenyl)-furan-2-carboxamidine | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)-N3-(benzo[d][1,3]dioxol-5-ylmethyl)-N1-(thiophen-2-ylmethyl)propane-1,3-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 3-Methyl-pyridin-2-ylamine | Drug Info |
| CAI --- CAIX | SID144212941 | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(7-methoxy-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-methoxyphenyl)piperazin-1-yl)-1-phenylpropan-1-one | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(6-methoxy-3-methyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(Quinolin-5-yloxy)-ethyl]-pyrrolidin-3-ylmethoxy}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5LOX --- HRH1 | 1-{4-[4-(2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}ethoxy)phenyl]but-3-yn-1-yl}-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | (R)-4-(3,4-Difluoro-phenyl)-1,2-dimethyl-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid {3-[4-(2-cyano-4-fluoro-phenyl)-piperidin-1-yl]-propyl}-amide | Drug Info |
| ADRA1A --- HRH1 | N-((cis)-4-(4-(dimethylamino)-6-methylpyrimidin-2-ylamino)cyclohexyl)-3,5-bis(trifluoromethyl)benzamide | Drug Info |
| ADRA1A --- HRH1 | 4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine-3-carboxylic acid {3-[4-(4-fluoro-phenyl)-piperidin-1-yl]-propyl}-amide | Drug Info |
| ADRA1A --- HRH1 | trans-1-benzyl-3-dimethylamino-6-phenylpiperidine | Drug Info |
| CABL --- FGFR1 | ENMD-2076 | Drug Info |
| CAI --- CAIX | Estradiol 3,17-O,O-bis-sulfamate | Drug Info |
| Aurora --- VEGFR | 6-methoxy-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| AuroraA --- CDK4 | 2-3-7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino-phenyl-acetic acid | Drug Info |
| AuroraA --- STK1 | CHEMBL385049 | Drug Info |
| AuroraA --- STK1 | N-(2-(2-(1H-benzo[d]imidazol-2-ylamino)thiazol-5-yl)ethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | (3S,6R)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide | Drug Info |
| AuroraA --- STK1 | (Z)-3-(2-{[5-(N,N-Dimethylsulfamoyl)-2-oxoindolin-3-ylidene]-methyl}-4-oxo-4,5,6,7-tetrahydro-1H-indol-3-yl)propanoic Acid | Drug Info |
| AuroraA --- STK1 | 4-(5-Methyl-1H-pyrazol-3-ylamino)-2-(4-nitrobenzyl)-2Hphthalazin-1-one | Drug Info |
| AuroraA --- STK1 | N-2-fluorophenyl-2-3-7-3-4-hydroxymethyl-piperidin-1-yl-propoxy-6-methoxyquinazolin-4-ylamino-1H-pyrazol-5-yl-acetamide | Drug Info |
| AuroraA --- STK1 | N-(3-fluorophenyl)-2-{2-[(7-{2-[4-(hydroxyethyl)piperidin-1-yl]ethoxy}-6-methoxyquinazolin-4-yl)amino]-1,3-thiazol-5-yl}acetamide | Drug Info |
| AuroraA --- STK1 | 2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)-N-phenylthiazole-5-carboxamide | Drug Info |
| Beta PDGFR --- CABL | 4-methyl-N-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide | Drug Info |
| Beta PDGFR --- Ckit | 4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (5-methyl-furan-2-ylmethyl)-amide | Drug Info |
| BNOS --- Hepatocyte NOS | 7-Fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL354788 | Drug Info |
| BNOS --- Hepatocyte NOS | 3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-7-methyl-3H-imidazo[4,5-b]pyridin-3-yl)-methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N-(2-bromo-5-chlorobenzyl)-N,1-dimethylpiperidin-4-amine | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)-N3-(benzo[d][1,3]dioxol-5-ylmethyl)-N1-(thiazol-2-ylmethyl)propane-1,3-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-omega-nitro-L-arginine | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL1221659 | Drug Info |
| BNOS --- Hepatocyte NOS | 7-NITROINDAZOLE | Drug Info |
| CAI --- CAIX | 4-{4-[4-sulfamoylphenethylamino(thioxo)methylamino]phenylsulfonamidomethyl}-1-benzenesulfonamide | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[4-(4-methyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
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