| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T59190 | ||||
| Target Name | Protein kinase C, zeta type | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | Indolocarbazole analogue | Drug Info | IC50 = 3 nM | [1] | |
| RO-320432 | Drug Info | IC50 = 21 nM | |||
| LY-317644 | Drug Info | IC50 = 6400 nM | |||
| LY-326449 | Drug Info | IC50 = 630 nM | [2] | ||
| [2,2':5',2'']Terthiophen-4-yl-methanol | Drug Info | IC50 = 3000 nM | [3] | ||
| RO-316233 | Drug Info | IC50 = 550 nM | [4] | ||
| [2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde | Drug Info | IC50 = 700 nM | [3] | ||
| [2,2':5',2'']Terthiophene-4-carbaldehyde | Drug Info | IC50 = 5000 nM | [3] | ||
| Ro-32-0557 | Drug Info | IC50 = 6.8 nM | |||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2002 Jan 21;12(2):147-50.Mixed lineage kinase activity of indolocarbazole analogues. | ||||
| REF 2 | J Med Chem. 1996 Jul 5;39(14):2664-71.(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. | ||||
| REF 3 | Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82.Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. | ||||
| REF 4 | J Med Chem. 1992 Jan;35(1):177-84.Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. | ||||
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