| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T14317 | ||||
| Target Name | Metabotropic glutamate receptor | ||||
| Target Type | Research |
||||
| Drug Potency against Target | QUISQUALATE | Drug Info | IC50 = 25 nM | [534590] | |
| 2S,4R-4-METHYLGLUTAMATE | Drug Info | IC50 = 4000 nM | [530441] | ||
| Ethyl 2-amino-4,5-diphenylthiophene-3-carboxylate | Drug Info | IC50 = 4500 nM | [530441] | ||
| References | |||||
| Ref 534590 | J Med Chem. 1998 Mar 12;41(6):930-9.Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid. | ||||
| Ref 530441 | Eur J Med Chem. 2010 Jan;45(1):69-77. Epub 2009 Sep 16.Substituted 2-aminothiopen-derivatives: a potential new class of GluR6-antagonists. | ||||
| Ref 530441 | Eur J Med Chem. 2010 Jan;45(1):69-77. Epub 2009 Sep 16.Substituted 2-aminothiopen-derivatives: a potential new class of GluR6-antagonists. | ||||
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