| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T46365 | ||||
| Target Name | M-phase inducer phosphatase 2 | ||||
| Target Type | Discontinued |
||||
| Drug Potency against Target | 6,7-dibromoquinoline-5,8-dione | Drug Info | IC50 = 5300 nM | [529691] | |
| 4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione | Drug Info | IC50 = 4530 nM | [527986] | ||
| 5,6,7,8-tetrahydroanthracene-1,4-dione | Drug Info | IC50 = 9530 nM | [529817] | ||
| JUGLONE | Drug Info | IC50 = 1980 nM | [529817] | ||
| 3-isopropyl-4-phenylnaphthalene-1,2-dione | Drug Info | IC50 = 3230 nM | [527986] | ||
| 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione | Drug Info | IC50 = 8710 nM | [527986] | ||
| ADOCIAQUINONE B | Drug Info | IC50 = 70 nM | [529691] | ||
| 4-ethoxynaphthalene-1,2-dione | Drug Info | IC50 = 270 nM | [529817] | ||
| 3-isopropyl-4-(phenylthio)naphthalene-1,2-dione | Drug Info | IC50 = 10860 nM | [527986] | ||
| ANTHRAQUINONE | Drug Info | IC50 = 9510 nM | [529817] | ||
| NSC-95397 | Drug Info | IC50 = 3770 nM | [529691] | ||
| References | |||||
| Ref 529691 | Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. Epub 2008 Aug 7.Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. | ||||
| Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
| Ref 529817 | Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. Epub 2008 Nov 8.Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. | ||||
| Ref 529817 | Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. Epub 2008 Nov 8.Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. | ||||
| Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
| Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
| Ref 529691 | Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. Epub 2008 Aug 7.Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. | ||||
| Ref 529817 | Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. Epub 2008 Nov 8.Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. | ||||
| Ref 527986 | Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. | ||||
| Ref 529817 | Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. Epub 2008 Nov 8.Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. | ||||
| Ref 529691 | Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. Epub 2008 Aug 7.Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. | ||||
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