Target Validation Information
Target ID T64213
Target Name Transient receptor potential cation channel subfamily V member 4
Target Type
Research
Drug Potency against Target Pyrrolidin-1-yl-thiourea Drug Info IC50 = 3000 nM [527001]
CAPSAZEPINE Drug Info IC50 = 600 nM [526604]
IODORESINIFERATOXIN Drug Info IC50 = 4000 nM [527001]
MK-056 Drug Info IC50 = 110 nM [526897]
SC-0030 Drug Info IC50 = 37 nM [526897]
4-Pyridin-2-yl-piperazine-1-carboxylic acid amide Drug Info IC50 = 30 nM [527001]
References
Ref 527001Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.
Ref 526604Bioorg Med Chem Lett. 2003 May 5;13(9):1549-52.Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists.
Ref 527001Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.
Ref 526897Bioorg Med Chem Lett. 2003 Dec 15;13(24):4389-93.Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.
Ref 526897Bioorg Med Chem Lett. 2003 Dec 15;13(24):4389-93.Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.
Ref 527001Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.

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