| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T15556 | ||||
| Target Name | Plasminogen activator inhibitor-1 | ||||
| Target Type | Clinical Trial |
||||
| Drug Potency against Target | AR-HO29953XX | Drug Info | IC50 = 17800 nM | [527611] | |
| XR-5118 | Drug Info | IC50 = 8000 nM | [527117] | ||
| SIDEROXYLONAL A | Drug Info | IC50 = 3300 nM | [525438] | ||
| SIDEROXYLONAL B | Drug Info | IC50 = 5300 nM | [525438] | ||
| Sideroxylonal C | Drug Info | IC50 = 4700 nM | [525438] | ||
| References | |||||
| Ref 527611 | Bioorg Med Chem Lett. 2005 Aug 1;15(15):3514-8.Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1. | ||||
| Ref 527117 | J Med Chem. 2004 Jul 1;47(14):3491-4.Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. | ||||
| Ref 525438 | J Nat Prod. 1999 Feb;62(2):324-6.Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens. | ||||
| Ref 525438 | J Nat Prod. 1999 Feb;62(2):324-6.Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens. | ||||
| Ref 525438 | J Nat Prod. 1999 Feb;62(2):324-6.Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens. | ||||
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