Co-Target(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06046 | Target Info | |||
| Target Name | Nitric-oxide synthase endothelial (NOS3) | ||||
| Synonyms |
Nitric oxide synthase, endothelial; NOSIII; NOS,type III; NOS type III; Endothelial nitric oxide synthase; Endothelial NOS; ENOS; EC-NOS; Constitutive NOS; CNOS
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| Target Type | Clinical trial Target | ||||
| Gene Name | NOS3 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Co-Targets of This Target | Top | |||||
|---|---|---|---|---|---|---|
| Co-Target Name | Nitric-oxide synthase brain (NOS1) | Clinical trial Target | ||||
| UniProt ID | NOS1_HUMAN | |||||
| Gene Name | NOS1 | |||||
| Synonyms |
Peptidyl-cysteine S-nitrosylase NOS1; Nitric oxide synthase, brain; Neuronal NOS; NOS, type I; NOS type I; NNOS; NC-NOS; N-NOS; BNOS
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| Representative Drug(s) | L-NAME | Drug Info | IC50 = 150 nM | [1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J Med Chem. 2003 Mar 13;46(6):913-6. | ||||
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