Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T16769 Target Info
Target Name X-linked inhibitor of apoptosis protein (XIAP)
Synonyms
hILP; hIAP3; hIAP-3; Xlinked IAP; X-linked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAPlike protein; IAP3; IAP-like protein; IAP-3; E3 ubiquitinprotein ligase XIAP; E3 ubiquitin-protein ligase XIAP; Baculoviral IAP repeatcontaining protein 4; Baculoviral IAP repeat-containing protein 4; BIRC4; API3
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Target Type Clinical trial Target
Gene Name XIAP
Biochemical Class Acyltransferase
UniProt ID
XIAP_HUMAN
Co-Targets of This Target  Top
Co-Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target
UniProt ID BIRC2_HUMAN
Gene Name BIRC2
Synonyms
hIAP2; hIAP-2; TNFR2TRAFsignaling complex protein 2; TNFR2-TRAF-signaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; CIAP1; C-IAP1; Baculoviral IAP repeatcontaining protein 2; Baculoviral IAP repeat-containing protein 2; API1
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Representative Drug(s) AT-406 Drug Info Ki = 1.9 nM Click to Show More [1]
2 GDC-0152 Drug Info IC50 = 10.4 nM [2]
3 Birinapant Drug Info IC50 = 50 nM [3]
Co-Target Name Cellular inhibitor of apoptosis 2 (BIRC3) Clinical trial Target
UniProt ID BIRC3_HUMAN
Gene Name BIRC3
Synonyms
hIAP1; hIAP-1; TNFR2TRAFsignaling complex protein 1; TNFR2-TRAF-signaling complex protein 1; RNF49; RING-type E3 ubiquitin transferase BIRC3; RING finger protein 49; MIHC; Inhibitor of apoptosis protein 1; IAP1; IAP homolog C; CIAP2; C-IAP2; Baculoviral IAP repeatcontaining protein3; Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; API2
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Representative Drug(s) AT-406 Drug Info Ki = 5.1 nM Click to Show More [1]
2 GDC-0152 Drug Info IC50 = 12.9 nM [2]
Co-Target Name Melanoma inhibitor of apoptosis protein (ML-IAP) Patented-recorded Target
UniProt ID BIRC7_HUMAN
Gene Name BIRC7
Synonyms
UNQ5800/PRO19607/PRO21344; RNF50; RING-type E3 ubiquitin transferase BIRC7; RING finger protein 50; MLIAP; Livin; Kidney inhibitor of apoptosis protein; KIAP; Baculoviral IAP repeat-containing protein 7
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Representative Drug(s) GDC-0152 Drug Info Ki < 50 nM [4]
Co-Target Name Max-like protein X (MLX) Co-Target
UniProt ID MLX_HUMAN
Gene Name MLX
Synonyms
Class D basic helix-loop-helix protein 13; bHLHd13; Max-like bHLHZip protein; Protein BigMax; Transcription factor-like protein 4
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Representative Drug(s) GDC-0152 Drug Info Ki = 14 nM [4]
References  Top
REF 1 A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem. 2011 Apr 28;54(8):2714-26.
REF 2 Design of Potent pan-IAP and Lys-Covalent XIAP Selective Inhibitors Using a Thermodynamics Driven Approach. J Med Chem. 2018 Jul 26;61(14):6350-63.
REF 3 Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity. J Med Chem. 2015 Feb 12;58(3):1556-62.
REF 4 Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem. 2012 May 10;55(9):4101-13.

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