Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T27812 Target Info
Target Name Serotonin transporter (SERT)
Synonyms
Solute carrier family 6 member 4; HTT; 5HTT; 5HT transporter
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Target Type Successful Target
Gene Name SLC6A4
Biochemical Class Neurotransmitter:sodium symporter
UniProt ID
SC6A4_HUMAN
Co-Targets of This Target  Top
Co-Target Name 5-HT 1A receptor (HTR1A) Successful Target
UniProt ID 5HT1A_HUMAN
Gene Name HTR1A
Synonyms
Serotonin receptor 1A; G-21; ADRBRL1; ADRB2RL1; 5-hydroxytryptamine receptor 1A; 5-HT1A receptor; 5-HT1A; 5-HT-1A
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Representative Drug(s) Vilazodone Drug Info EC50 = 0.12 nM Click to Show More [1]
2 Vortioxetine Drug Info Ki = 9.5 nM [10]
3 Vortioxetine Drug Info Ki = 15 nM [6]
Co-Target Name Histamine H1 receptor (H1R) Successful Target
UniProt ID HRH1_HUMAN
Gene Name HRH1
Synonyms
HH1R; H1R
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Representative Drug(s) Amitriptyline Drug Info Ki = 1.12 nM Click to Show More [2]
2 Vortioxetine Drug Info Ki = 180 nM [6]
Co-Target Name Dopamine transporter (DAT) Successful Target
UniProt ID SC6A3_HUMAN
Gene Name SLC6A3
Synonyms
Solute carrier family 6 member 3; Sodium-dependent dopamine transporter; DAT1; DAT; DA transporter
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Representative Drug(s) Fluvoxamine Drug Info Ki = 1.46 nM Click to Show More [3]
2 Cocaine Drug Info Ki = 32 nM [13]
3 Amitifadine Drug Info Ki = 79.43 nM [18]
4 Duloxetine Drug Info Ki = 240 nM [23]
5 Sertraline Drug Info IC50 = 310 nM [24]
6 Paroxetine Drug Info Ki = 400 nM [19]
7 Bupropion Drug Info Ki = 441 nM [26]
8 Desvenlafaxine Drug Info Ki ~ 854 nM [30]
9 Venlafaxine Drug Info Ki ~ 890 nM [30]
10 METHYLENEDIOXYMETHAMPHETAMINE Drug Info Ki = 897 nM [25]
11 Bicifadine Drug Info IC50 = 910 nM [16]
Co-Target Name Norepinephrine transporter (NET) Successful Target
UniProt ID SC6A2_HUMAN
Gene Name SLC6A2
Synonyms
Solute carrier family 6 member 2; Sodium-dependent noradrenaline transporter; SLC6A2; NET1; NET; NAT1
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Representative Drug(s) Duloxetine Drug Info IC50 = 1.585 nM Click to Show More [4]
2 Nortriptyline Drug Info Ki = 6.3 nM [8]
3 Amitifadine Drug Info IC50 = 22.8 nM [12]
4 Levomilnacipran Drug Info IC50 = 40 nM [15]
5 Bicifadine Drug Info IC50 = 55 nM [16]
6 Clomipramine Drug Info IC50 = 64.6 nM [17]
7 Paroxetine Drug Info Ki = 90 nM [19]
8 Cocaine Drug Info Ki = 108 nM [20]
9 Venlafaxine Drug Info IC50 = 149 nM [22]
10 Amitriptyline Drug Info Ki = 333 nM [25]
11 METHYLENEDIOXYMETHAMPHETAMINE Drug Info Ki = 398 nM [25]
12 Fluoxetine Drug Info Ki = 440 nM [19]
13 Bupropion Drug Info IC50 = 443 nM [27]
14 Desvenlafaxine Drug Info IC50 = 538 nM [16]
15 Sertraline Drug Info IC50 = 825 nM [24]
Co-Target Name Neuronal acetylcholine receptor alpha-3/beta-4 (CHRNA3/B4) Successful Target
UniProt ID ACHA3_HUMAN-ACHB4_HUMAN
Gene Name CHRNA3-CHRNB4
Synonyms
Neuronal acetylcholine receptor
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Representative Drug(s) Bupropion Drug Info IC50 = 1.8 nM [5]
Co-Target Name 5-HT 3A receptor (HTR3A) Successful Target
UniProt ID 5HT3A_HUMAN
Gene Name HTR3A
Synonyms
Serotonin-gated ion channel receptor; Serotonin receptor 3A; HTR3; 5HT3R; 5-hydroxytryptamine receptor 3A; 5-HT3RA; 5-HT3A; 5-HT3-A; 5-HT 3A
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Representative Drug(s) Vortioxetine Drug Info Ki = 3.7 nM [6]
Co-Target Name Voltage-gated potassium channel Kv11.1 (KCNH2) Successful Target
UniProt ID KCNH2_HUMAN
Gene Name KCNH2
Synonyms
hERG1; hERG-1; Voltage-gated potassium channel subunit Kv11.1; Potassium voltage-gated channel subfamily H member 2; HERG K+ channel; HERG; H-ERG; Ether-a-go-go-related protein 1; Ether-a-go-go-related gene potassium channel 1; Ether-a-go-go related protein 1; Ether-a-go-go related gene potassium channel 1; Eag related protein 1; Eag homolog; ERG-1; ERG
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Representative Drug(s) Cocaine Drug Info IC50 = 4.4 nM Click to Show More [7]
2 Fluoxetine Drug Info IC50 = 10 nM [11]
3 Citalopram Drug Info IC50 = 10 nM [11]
Co-Target Name Adrenergic receptor alpha-2A (ADRA2A) Successful Target
UniProt ID ADA2A_HUMAN
Gene Name ADRA2A
Synonyms
Alpha-2AAR; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptor subtype C10; ADRAR; ADRA2R
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Representative Drug(s) Fluoxetine Drug Info Ki = 6.31 nM [9]
Co-Target Name Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) Successful Target
UniProt ID ACHA4_HUMAN-ACHB2_HUMAN
Gene Name CHRNA4-CHRNB2
Synonyms
CHRN; nAChR
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Representative Drug(s) Bupropion Drug Info IC50 = 12 nM [5]
Co-Target Name 5-HT 1B receptor (HTR1B) Successful Target
UniProt ID 5HT1B_HUMAN
Gene Name HTR1B
Synonyms
Serotonin receptor 1B; Serotonin 1D beta receptor; S12; HTR1DB; 5-hydroxytryptamine receptor 1B; 5-HT1B receptor; 5-HT1B; 5-HT-1D-beta; 5-HT-1B
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Representative Drug(s) Vortioxetine Drug Info Ki = 33 nM [6]
Co-Target Name Opioid receptor sigma 1 (OPRS1) Successful Target
UniProt ID SGMR1_HUMAN
Gene Name SIGMAR1
Synonyms
hSigmaR1; Sigma1R; Sigma1-receptor; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; SRBP; SR31747-binding protein; SR31747 binding protein 1; SR-BP; SIG-1R; Opioid receptor, sigma 1, isoform 1; OPRS1 protein; Aging-associated gene 8 protein; AAG8
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Representative Drug(s) Fluvoxamine Drug Info Ki = 36 nM Click to Show More [14]
2 Sertraline Drug Info Ki = 57 nM [14]
3 Fluoxetine Drug Info IC50 = 851.14 nM [29]
Co-Target Name Adrenergic receptor beta-1 (ADRB1) Successful Target
UniProt ID ADRB1_HUMAN
Gene Name ADRB1
Synonyms
Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenergic receptor; B1AR; ADRB1R
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Representative Drug(s) Vortioxetine Drug Info Ki = 46 nM [6]
Co-Target Name Dopamine D1 receptor (D1R) Successful Target
UniProt ID DRD1_HUMAN
Gene Name DRD1
Synonyms
D(1A) dopamine receptor
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Representative Drug(s) Amitriptyline Drug Info Ki = 89 nM [2]
Co-Target Name Acetylcholinesterase (AChE) Successful Target
UniProt ID ACES_HUMAN
Gene Name ACHE
Synonyms
YT; N-ACHE; ARACHE
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Representative Drug(s) Fluoxetine Drug Info IC50 = 130 nM [21]
Co-Target Name Dopamine D5 receptor (D5R) Successful Target
UniProt ID DRD5_HUMAN
Gene Name DRD5
Synonyms
Dopamine receptor 5; DRD5; D1beta dopamine receptor; D(5)D(1B) dopamine receptor dopamine receptor; D(5) dopamine receptor
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Representative Drug(s) Amitriptyline Drug Info Ki = 170 nM [2]
Co-Target Name Histamine H2 receptor (H2R) Successful Target
UniProt ID HRH2_HUMAN
Gene Name HRH2
Synonyms
Histamine receptor 2; HH2R; Gastric receptor I
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Representative Drug(s) Vortioxetine Drug Info Ki = 180 nM [6]
Co-Target Name 5-HT 2A receptor (HTR2A) Successful Target
UniProt ID 5HT2A_HUMAN
Gene Name HTR2A
Synonyms
Serotonin receptor 2A; HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT-2
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Representative Drug(s) Vortioxetine Drug Info Ki = 180 nM [6]
Co-Target Name 5-HT 2C receptor (HTR2C) Successful Target
UniProt ID 5HT2C_HUMAN
Gene Name HTR2C
Synonyms
Serotonin receptor 2C; HTR1C; 5HT-1C; 5-hydroxytryptamine receptor 2C; 5-hydroxytryptamine receptor 1C; 5-HTR2C; 5-HT2C receptor; 5-HT2C; 5-HT1C; 5-HT-2C; 5-HT-1C
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Representative Drug(s) Vortioxetine Drug Info Ki = 180 nM [6]
Co-Target Name Dopamine D2 receptor (D2R) Successful Target
UniProt ID DRD2_HUMAN
Gene Name DRD2
Synonyms
Dopamine receptor 2; D(2) dopamine receptor
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Representative Drug(s) Amitriptyline Drug Info Ki = 196 nM Click to Show More [2]
2 Vilazodone Drug Info Ki = 666 nM [28]
Co-Target Name Dopamine D3 receptor (D3R) Successful Target
UniProt ID DRD3_HUMAN
Gene Name DRD3
Synonyms
D(3) dopamine receptor
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Representative Drug(s) Amitriptyline Drug Info Ki = 206 nM [2]
Co-Target Name 5-HT 5A receptor (HTR5A) Successful Target
UniProt ID 5HT5A_HUMAN
Gene Name HTR5A
Synonyms
Serotonin receptor 5A; 5-hydroxytryptamine receptor 5A; 5-HT5A; 5-HT-5A; 5-HT-5; 5-HT 5A
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Representative Drug(s) Vortioxetine Drug Info Ki = 220 nM [6]
Co-Target Name Adrenergic receptor beta-2 (ADRB2) Successful Target
UniProt ID ADRB2_HUMAN
Gene Name ADRB2
Synonyms
Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Beta-2 adrenergic receptor; B2AR; ADRB2R
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Representative Drug(s) Vortioxetine Drug Info Ki = 560 nM [6]
Co-Target Name Substance-P receptor (TACR1) Successful Target
UniProt ID NK1R_HUMAN
Gene Name TACR1
Synonyms
Tachykinin receptor 1; Tachykinin neurokinin 1 receptor; Tachykinin 1 receptor; TACR1; Substance P receptor; SPR; Neurokinin 1 receptor; NK-1R; NK-1 receptor
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Representative Drug(s) Paroxetine Drug Info IC50 = 900 nM [31]
Co-Target Name Debrisoquine 4-hydroxylase (CYP2D6) Successful Target
UniProt ID CP2D6_HUMAN
Gene Name CYP2D6
Synonyms
P450-DB1; Cytochrome P450-DB1; Cytochrome P450 2D6; CYPIID6; CYP2DL1
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Representative Drug(s) Paroxetine Drug Info IC50 = 960 nM Click to Show More [32]
2 Duloxetine Drug Info IC50 = 1000 nM [33]
Co-Target Name 5-HT 7 receptor (HTR7) Clinical trial Target
UniProt ID 5HT7R_HUMAN
Gene Name HTR7
Synonyms
Serotonin receptor 7; 5HT7; 5-hydroxytryptamine receptor 7; 5-HT7 receptor; 5-HT7; 5-HT-X; 5-HT-7
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Representative Drug(s) Vortioxetine Drug Info Ki = 19 nM Click to Show More [6]
2 Vortioxetine Drug Info Ki = 26 nM [35]
Co-Target Name Myeloperoxidase (MPO) Clinical trial Target
UniProt ID PERM_HUMAN
Gene Name MPO
Synonyms
MPO
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Representative Drug(s) Paroxetine Drug Info IC50 = 20 nM [34]
Co-Target Name 5-HT 6 receptor (HTR6) Clinical trial Target
UniProt ID 5HT6R_HUMAN
Gene Name HTR6
Synonyms
Serotonin receptor 6; 5-hydroxytryptamine receptor 6; 5-HT6 receptor; 5-HT6; 5-HT-6
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Representative Drug(s) Clomipramine Drug Info Ki = 112 nM Click to Show More [36]
2 Nortriptyline Drug Info Ki = 214 nM [36]
3 Vortioxetine Drug Info Ki = 330 nM [6]
Co-Target Name Albendazole monooxygenase (CYP3A4) Clinical trial Target
UniProt ID CP3A4_HUMAN
Gene Name CYP3A4
Synonyms
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
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Representative Drug(s) Duloxetine Drug Info IC50 = 440 nM Click to Show More [37]
2 Sertraline Drug Info IC50 = 800 nM [24]
Co-Target Name Voltage-gated sodium channel alpha Nav1.7 (SCN9A) Clinical trial Target
UniProt ID SCN9A_HUMAN
Gene Name SCN9A
Synonyms
hNE-Na; Voltage-gated sodium channel subunit alpha Nav1.7; Sodium channel proteintype IX subunit alpha; Sodium channel proteintype 9 subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type 9 subunit alpha; Peripheral sodium channel 1; PN1; Neuroendocrine sodium channel; NENA
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Representative Drug(s) Amitriptyline Drug Info IC50 = 1000 nM [38]
Co-Target Name Histamine H3 receptor (H3R) Clinical trial Target
UniProt ID HRH3_HUMAN
Gene Name HRH3
Synonyms
Histamine receptor 3; HH3R; GPCR97; G-protein coupled receptor 97; G protein-coupled receptor 97
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Representative Drug(s) Amitriptyline Drug Info Ki ~ 1000 nM [2]
Co-Target Name Acetylcholine receptor alpha-1/beta-1/delta/gamma (CHRNA1/CHRNA1/CHRND/CHRNG) Co-Target
UniProt ID ACHA_HUMAN-ACHB_HUMAN-ACHD_HUMAN-ACHG_HUMAN
Gene Name CHRNA1-CHRNB1-CHRND-CHRNG
Representative Drug(s) Bupropion Drug Info IC50 = 7.9 nM [5]
Co-Target Name Neuronal acetylcholine receptor alpha4/beta4 (CHRNA4/CHRNB4) Co-Target
UniProt ID ACHA4_HUMAN; ACHB4_HUMAN
Gene Name CHRNA4; CHRNB4
Representative Drug(s) Bupropion Drug Info IC50 = 15 nM [5]
Co-Target Name Cytochrome P450 2C19 (CYP2C19) Co-Target
UniProt ID CP2CJ_HUMAN
Gene Name CYP2C19
Synonyms
Fenbendazole monooxygenase (4'-hydroxylating); (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase
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Representative Drug(s) Fluoxetine Drug Info IC50 = 40 nM Click to Show More [39]
2 Sertraline Drug Info IC50 = 310 nM [24]
Co-Target Name Neuronal acetylcholine receptor alpha3/beta2 (CHRNA3/CHRNB2) Co-Target
UniProt ID ACHA3_HUMAN; ACHB2_HUMAN
Gene Name CHRNA3; CHRNB2
Representative Drug(s) Bupropion Drug Info IC50 = 1000 nM [40]
References  Top
REF 1 Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. Bioorg Med Chem. 2018 Jul 23;26(12):3117-25.
REF 2 Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett. 2009 Jan 15;19(2):538-42.
REF 3 Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography. J Med Chem. 2003 Mar 13;46(6):925-35.
REF 4 A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1456-61.
REF 5 Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14.
REF 6 Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21.
REF 7 Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. J Med Chem. 2002 Aug 29;45(18):3844-53.
REF 8 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8.
REF 9 Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties. J Med Chem. 2001 Mar 1;44(5):787-805.
REF 10 Synthesis and antidepressant activity of a series of arylalkanol and aralkyl piperazine derivatives targeting SSRI/5-HT. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5420-3.
REF 11 Polypharmacology-foe or friend? J Med Chem. 2013 Nov 27;56(22):8955-71.
REF 12 Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6.
REF 13 Synthesis and ligand binding of eta(6)-(2beta-carbomethoxy-3beta-phenyltropane) transition metal complexes. J Med Chem. 1996 Mar 29;39(7):1560-3.
REF 14 From alpha4beta2 Nicotinic Ligands to the Discovery of sigma1 Receptor Ligands: Pharmacophore Analysis and Rational Design. ACS Med Chem Lett. 2012 Dec 13;3(12):1054-8.
REF 15 Studies on a series of milnacipran analogs containing a heteroaromatic group as potent norepinephrine and serotonin transporter inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3230-5.
REF 16 Triple Reuptake Inhibitors as Potential Therapeutics for Depression and Other Disorders: Design Paradigm and Developmental Challenges. J Med Chem. 2018 Mar 22;61(6):2133-65.
REF 17 Synthesis and biological evaluation of novel 3,4-diaryl lactam derivatives as triple reuptake inhibitors. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5515-8.
REF 18 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem. 2010 Jul 8;53(13):4989-5001.
REF 19 Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors. J Med Chem. 2005 Sep 22;48(19):6023-34.
REF 20 Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorg Med Chem Lett. 2003 Feb 10;13(3):513-7.
REF 21 Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods. Eur J Med Chem. 2010 Mar;45(3):1167-72.
REF 22 Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem. 2011 Apr 28;54(8):2529-91.
REF 23 Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4477-80.
REF 24 Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors. Bioorg Med Chem. 2011 Jan 1;19(1):663-76.
REF 25 An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3411-5.
REF 26 A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorg Med Chem. 2009 Jun 1;17(11):3770-4.
REF 27 Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81.
REF 28 Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. Eur J Med Chem. 2012 Jul;53:124-32.
REF 29 Conformational analysis, pharmacophore identification, and comparative molecular field analysis of ligands for the neuromodulatory sigma 3 receptor. J Med Chem. 1994 Nov 25;37(24):4109-17.
REF 30 Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor. ACS Med Chem Lett. 2013 May 7;4(6):560-4.
REF 31 Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression. Bioorg Med Chem. 2013 Apr 15;21(8):2217-28.
REF 32 Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug Metab Dispos. 2012 May;40(5):943-51.
REF 33 4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2009 May 15;19(10):2829-34.
REF 34 Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure. J Med Chem. 2017 Aug 10;60(15):6563-6586.
REF 35 Synthesis and antidepressant-like activity of novel alkoxy-piperidine derivatives targeting SSRI/5-HT 1A/5-HT 7. Bioorg Med Chem Lett. 2019 Dec 15;29(24):126769.
REF 36 Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers. J Med Chem. 2012 Jun 28;55(12):5704-19.
REF 37 Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3234-7.
REF 38 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80.
REF 39 Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). Eur J Med Chem. 2015 Oct 20;103:210-22.
REF 40 Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem. 2005 Jul 28;48(15):4705-45.

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