Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T51408 Target Info
Target Name Adrenergic receptor beta-3 (ADRB3)
Synonyms
Beta3AR; Beta3-AR; Beta-3 adrenoreceptor; Beta-3 adrenoceptor; Beta-3 adrenergic receptor; B3AR; ADRB3R
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Target Type Successful Target
Gene Name ADRB3
Biochemical Class GPCR rhodopsin
UniProt ID
ADRB3_HUMAN
Co-Targets of This Target  Top
Co-Target Name Adrenergic receptor beta-2 (ADRB2) Successful Target
UniProt ID ADRB2_HUMAN
Gene Name ADRB2
Synonyms
Beta-2 adrenoreceptor; Beta-2 adrenoceptor; Beta-2 adrenergic receptor; B2AR; ADRB2R
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Representative Drug(s) LY-377604 Drug Info Ki = 0.012 nM [1]
Co-Target Name Adrenergic receptor beta-1 (ADRB1) Successful Target
UniProt ID ADRB1_HUMAN
Gene Name ADRB1
Synonyms
Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenergic receptor; B1AR; ADRB1R
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Representative Drug(s) LY-377604 Drug Info Ki = 0.023 nM Click to Show More [1]
2 GW-427353 Drug Info Ki = 398.11 nM [2]
References  Top
REF 1 Combination of a Beta adrenoceptor modulator and a norepinephrine-serotonin uptake inhibitor for the treatment of obesity. ACS Med Chem Lett. 2011 May 23;2(8):583-6.
REF 2 Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists. J Med Chem. 2006 May 4;49(9):2758-71.

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