Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T64591 Target Info
Target Name 5-HT 3A receptor (HTR3A)
Synonyms
Serotonin-gated ion channel receptor; Serotonin receptor 3A; HTR3; 5HT3R; 5-hydroxytryptamine receptor 3A; 5-HT3RA; 5-HT3A; 5-HT3-A; 5-HT 3A
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Target Type Successful Target
Gene Name HTR3A
Biochemical Class GPCR rhodopsin
UniProt ID
5HT3A_HUMAN
Co-Targets of This Target  Top
Co-Target Name 5-HT 1A receptor (HTR1A) Successful Target
UniProt ID 5HT1A_HUMAN
Gene Name HTR1A
Synonyms
Serotonin receptor 1A; G-21; ADRBRL1; ADRB2RL1; 5-hydroxytryptamine receptor 1A; 5-HT1A receptor; 5-HT1A; 5-HT-1A
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Representative Drug(s) Tropisetron Drug Info Ki = 5.3 nM [1]
Co-Target Name Neuronal acetylcholine receptor alpha-7 (CHRNA7) Successful Target
UniProt ID ACHA7_HUMAN
Gene Name CHRNA7
Synonyms
Nicotinic acetylcholine receptor subunit alpha 7; Nicotinic acetylcholine receptor alpha7; CHRNA7; Alpha7 nicotinic receptor; Alpha7 nAChR; Alpha-7 nAChR; Alpha(7) nicotinic receptor
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Representative Drug(s) Tropisetron Drug Info Ki = 6.9 nM [2]
Co-Target Name 5-HT 4 receptor (HTR4) Successful Target
UniProt ID 5HT4R_HUMAN
Gene Name HTR4
Synonyms
Serotonin receptor 4; 5-hydroxytryptamine receptor 4; 5-HT4 receptor; 5-HT4; 5-HT-4
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Representative Drug(s) Tropisetron Drug Info Ki = 199.53 nM [3]
Co-Target Name Albendazole monooxygenase (CYP3A4) Clinical trial Target
UniProt ID CP3A4_HUMAN
Gene Name CYP3A4
Synonyms
Taurochenodeoxycholate 6-alpha-hydroxylase; Quinine 3-monooxygenase; P450-PCN1; Nifedipine oxidase; NF-25; HLp; Cytochrome P450-PCN1; Cytochrome P450 NF-25; Cytochrome P450 HLp; Cytochrome P450 3A4; Cytochrome P450 3A3; CYPIIIA4; CYPIIIA3; CYP3A3; Albendazole sulfoxidase; Albendazole monooxygenase (sulfoxide-forming); 1,8-cineole 2-exo-monooxygenase
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Representative Drug(s) Alosetron Drug Info IC50 = 600 nM [4]
References  Top
REF 1 Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43.
REF 2 Discovery and development of alpha7 nicotinic acetylcholine receptor modulators. J Med Chem. 2011 Dec 8;54(23):7943-61.
REF 3 Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines. Bioorg Med Chem. 2009 Mar 15;17(6):2607-22.
REF 4 The discovery of diazepinone-based 5-HT3 receptor partial agonists. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2578-81.

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