Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03KPA
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| Former ID |
DNC004559
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| Drug Name |
5-Ethyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole
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| Synonyms |
CHEMBL49048; 5-Ethyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole; SCHEMBL8506288; PWLIYMBPGFVKOO-UHFFFAOYSA-N; BDBM50090520; 3-(2-Pyrrolizinoethyl)-5-ethyl-1H-indole; 5-ethyl-3-(2-pyrrolidinylethyl) -1H-indole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H22N2
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| Canonical SMILES |
CCC1=CC2=C(C=C1)NC=C2CCN3CCCC3
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| InChI |
1S/C16H22N2/c1-2-13-5-6-16-15(11-13)14(12-17-16)7-10-18-8-3-4-9-18/h5-6,11-12,17H,2-4,7-10H2,1H3
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| InChIKey |
PWLIYMBPGFVKOO-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1B receptor (HTR1B) | Target Info | Inhibitor | [1] |
| 5-HT 1D receptor (HTR1D) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9. | |||
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