Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D03PYX
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| Former ID |
DIB018224
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| Drug Name |
[3H]7-OH-DPAT
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| Synonyms |
7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol; 7-OH-DPAT; 7-Ohdpat; DP-7-AT; 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol; 7-Hydroxy-N,N-di-n-propyl-2-aminotetralin; 7-Hydroxy-2-N,N-dipropylaminotetralin; N,N-Di-n-propyl-7-hydroxy-2-aminotetralin; CHEMBL285755; 7-(Dipropylamino)-5,6,7,8-tetrahydro-2-naphthalenol; 2-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-; 7-Hydroxy-DPAT hydrobromide; (+)-7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol hydrobromide; [3H]-7-OH-DPAT; (+)7-OH-DPAT; AC1Q7AGR; AC1L1AZK; [3H]-7-OH-DPAT; (+/-)-7-hydroxy-2-(N,N-di-n-propylamino)tetralin
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2], [3] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H25NO
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| Canonical SMILES |
CCCN(CCC)C1CCC2=C(C1)C=C(C=C2)O
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| InChI |
1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3
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| InChIKey |
BLYMJBIZMIGWFK-UHFFFAOYSA-N
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| CAS Number |
CAS 74938-11-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:111176
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine D2 receptor (D2R) | Target Info | Inhibitor | [3] |
| Dopamine D3 receptor (D3R) | Target Info | Agonist | [3], [4], [5] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Dopaminergic synapse | ||||
| Rap1 signaling pathway | ||||
| cAMP signaling pathway | ||||
| Gap junction | ||||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Nicotine pharmacodynamics pathway | ||||
| Reactome | Dopamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| GPCRs, Other | ||||
| Hypothetical Network for Drug Addiction | ||||
| Genes and (Common) Pathways Underlying Drug Addiction | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 950). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3296). | |||
| REF 3 | Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding character... J Med Chem. 2008 Dec 25;51(24):7806-19. | |||
| REF 4 | Radioligand binding characterization of putative dopamine D3 receptor in human peripheral blood lymphocytes with [3H]7-OH-DPAT. J Neuroimmunol. 1995 May;58(2):139-44. | |||
| REF 5 | 7-OH-DPAT and PD 128907 selectively activate the D3 dopamine receptor in a novel environment. Neuropsychopharmacology. 2003 Jan;28(1):100-7. | |||
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