Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D03SFN
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| Former ID |
DCL000793
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| Drug Name |
Elzasonan hydrochloride
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| Synonyms |
Elzasonan HCl; CP 448187-01; Elzasonan hydrochloride (USAN); (2E)-4-(3,4-dichlorophenyl)-2-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one hydrochloride; (2Z)-4-(3,4-dichlorophenyl)-2-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one hydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Mood disorder [ICD-11: 6A60-6E23; ICD-9: 296] | Discontinued in Phase 2 | [1] | |
| Company |
Pfizer
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| Structure |
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Download2D MOL |
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| Formula |
C22H24Cl3N3OS
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| Canonical SMILES |
CN1CCN(CC1)C2=CC=CC=C2C=C3C(=O)N(CCS3)C4=CC(=C(C=C4)Cl)Cl.Cl
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| InChI |
1S/C22H23Cl2N3OS.ClH/c1-25-8-10-26(11-9-25)20-5-3-2-4-16(20)14-21-22(28)27(12-13-29-21)17-6-7-18(23)19(24)15-17;/h2-7,14-15H,8-13H2,1H3;1H/b21-14-;
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| InChIKey |
NMTRXBJYASHMND-UXTSPRGOSA-N
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| CAS Number |
CAS 220322-05-4
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1B receptor (HTR1B) | Target Info | Modulator | [2] |
| 5-HT 1D receptor (HTR1D) | Target Info | Modulator | [2] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. | |||
| REF 2 | DOI: 10.1002/9781118541203.xen439 | |||
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