Drug Information
Drug General Information | Top | |||
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Drug ID |
D05AZW
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Former ID |
DNC010484
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Drug Name |
Alstiphyllanine E
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Synonyms |
Alstiphyllanine E; CHEMBL592477
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C30H32N2O7
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Canonical SMILES |
CC=C1CN2C3CC1C(C45C3(NC6=CC=CC=C64)OC2C5)(COC(=O)C7=CC(=C(C=C7)OC)OC)C(=O)OC
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InChI |
1S/C30H32N2O7/c1-5-17-15-32-24-13-20(17)28(27(34)37-4,16-38-26(33)18-10-11-22(35-2)23(12-18)36-3)29-14-25(32)39-30(24,29)31-21-9-7-6-8-19(21)29/h5-12,20,24-25,31H,13-16H2,1-4H3/b17-5-/t20-,24-,25-,28-,29-,30-/m0/s1
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InChIKey |
NPAPHJSGCRCHBM-UMLFCLJTSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | SLC5A2 messenger RNA (SLC5A2 mRNA) | Target Info | Inhibitor | [1] |
Sodium/glucose cotransporter 1 (SGLT1) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Carbohydrate digestion and absorption | |||
Bile secretion | ||||
Mineral absorption | ||||
Pathwhiz Pathway | Lactose Degradation | |||
Trehalose Degradation | ||||
Reactome | Hexose transport | |||
Na+-dependent glucose transporters | ||||
Inositol transporters | ||||
WikiPathways | NRF2 pathway | |||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
Metabolism of carbohydrates |
References | Top | |||
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REF 1 | Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. |
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