Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06FPQ
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| Former ID |
DAP000063
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| Drug Name |
Frovatriptan
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| Synonyms |
Allegro; Auradol; Frova; Frovelan; Migard; Miguard; Rilamig; Allergo filmtabletten; SB 209509; Allergo filmtabletten(TN); Frova (TN); Frovatriptan (INN); SB-209509; (3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide; (6R)-6-(methylamino)-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide; (R)-5,6,7,8-Tetrahydro-6-(methylamino)carbazole-3-carboxamide
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| Drug Type |
Small molecular drug
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| Indication | Migraine [ICD-11: 8A80; ICD-10: G43, G43.9; ICD-9: 346] | Approved | [1], [2] | |
| Therapeutic Class |
Antimigraine Agents
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| Company |
Vernalis
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H17N3O
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| Canonical SMILES |
CNC1CCC2=C(C1)C3=C(N2)C=CC(=C3)C(=O)N
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| InChI |
1S/C14H17N3O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18)/t9-/m1/s1
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| InChIKey |
XPSQPHWEGNHMSK-SECBINFHSA-N
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| CAS Number |
CAS 158747-02-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7979332, 8199305, 12014901, 14749650, 15221001, 43133577, 46506288, 48416039, 50070536, 50071300, 50288893, 57332463, 93167160, 96024690, 103396317, 103967002, 104368726, 126658118, 126667006, 129723338, 134223840, 134337391, 135035469, 137002444, 138365609, 160964334, 175265638, 178103766, 179150020, 184527647, 223660569, 226420875
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| ChEBI ID |
CHEBI:134991
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| ADReCS Drug ID | BADD_D00976 ; BADD_D00977 | |||
| SuperDrug ATC ID |
N02CC07
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| SuperDrug CAS ID |
cas=158747025
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1B receptor (HTR1B) | Target Info | Modulator | [3] |
| 5-HT 1D receptor (HTR1D) | Target Info | Modulator | [3] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7191). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | |||
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