Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06XXH
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| Former ID |
DNCL002725
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| Drug Name |
Dacomitinib
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| Synonyms |
PF-00299804
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| Drug Type |
Small molecular drug
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| Indication | Non-small-cell lung cancer [ICD-11: 2C25.Y; ICD-9: 162] | Approved | [1] | |
| Company |
Pfizer
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H25ClFN5O2
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| Canonical SMILES |
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)C=CCN4CCCCC4
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| InChI |
1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+
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| InChIKey |
LVXJQMNHJWSHET-AATRIKPKSA-N
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| CAS Number |
CAS 1110813-31-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
16613030, 23640600, 74609599, 135263265, 135626635, 136340260, 136349571, 136367702, 140977763, 152159560, 152258509, 160647344, 162011542, 162038136, 162205175, 164041746, 172918917, 174505192, 174526192, 178103994, 185997026, 189622863, 194690240, 198956821, 223382341, 223705276, 252109876, 252216044, 252451737, 252451797
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| ChEBI ID |
CHEBI:91466
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7422). | |||
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