Drug Information
Drug General Information | Top | |||
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Drug ID |
D08BFU
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Former ID |
DNC013593
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Drug Name |
ASTRAGALIN
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Synonyms |
Astragalin; 480-10-4; Astragaline; kaempferol-3-glucoside; Kaempferol 3-O-glucoside; Kaempferol 3-glucoside; Kaempferol-3-O-glucoside; asragalin; Kaempferol-3-beta-monoglucoside; Kaempferol-3-D-glucoside; Kaempferol-3-beta-glucopyranoside; UNII-APM8UQ3Z9O; 3,4',5,7-Tetrahydroxyflavone-3-glucoside; Kaempferol 3-O-beta-D-glucopyranoside; 3-Glucosylkaempferol; Kaempferol 3-O-beta-D-glucoside; APM8UQ3Z9O; 4H-1-Benzopyran-4-one, 3-(beta-D-glucopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-; CHEMBL233930; CHEBI:30200
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C21H20O11
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Canonical SMILES |
C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O
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InChI |
1S/C21H20O11/c22-7-13-15(26)17(28)18(29)21(31-13)32-20-16(27)14-11(25)5-10(24)6-12(14)30-19(20)8-1-3-9(23)4-2-8/h1-6,13,15,17-18,21-26,28-29H,7H2/t13-,15-,17+,18-,21+/m1/s1
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InChIKey |
JPUKWEQWGBDDQB-QSOFNFLRSA-N
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CAS Number |
CAS 480-10-4
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:30200
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Target and Pathway | Top | |||
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Target(s) | Aldose reductase (AKR1B1) | Target Info | Inhibitor | [2] |
Angiotensin-converting enzyme (ACE) | Target Info | Inhibitor | [1] | |
BioCyc | Methylglyoxal degradation III | |||
Acetone degradation I (to methylglyoxal) | ||||
KEGG Pathway | Renin-angiotensin system | |||
Chagas disease (American trypanosomiasis) | ||||
Hypertrophic cardiomyopathy (HCM) | ||||
Pentose and glucuronate interconversions | ||||
Fructose and mannose metabolism | ||||
Galactose metabolism | ||||
Glycerolipid metabolism | ||||
Metabolic pathways | ||||
NetPath Pathway | IL1 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
Pathwhiz Pathway | Angiotensin Metabolism | |||
Fructose and Mannose Degradation | ||||
Pyruvate Metabolism | ||||
Pterine Biosynthesis | ||||
Glycerolipid Metabolism | ||||
Galactose Metabolism | ||||
Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
WikiPathways | ACE Inhibitor Pathway | |||
Metabolism of Angiotensinogen to Angiotensins | ||||
Metapathway biotransformation | ||||
Polyol Pathway | ||||
Metabolism of steroid hormones and vitamin D |
References | Top | |||
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REF 1 | Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity. J Nat Prod. 1987 Jul-Aug;50(4):680-3. | |||
REF 2 | Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod. 2008 Apr;71(4):713-5. |
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