Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D09AQJ
|
|||
Former ID |
DNC013677
|
|||
Drug Name |
D-203
|
|||
Synonyms |
CHEMBL468022; BDBM50261280
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
|||
Formula |
C24H37N5S
|
|||
Canonical SMILES |
CCCN(CCCCN1CCN(CC1)C2=CC=CC=C2)C3CCC4=C(C3)SC(=N4)N
|
|||
InChI |
1S/C24H37N5S/c1-2-12-28(21-10-11-22-23(19-21)30-24(25)26-22)14-7-6-13-27-15-17-29(18-16-27)20-8-4-3-5-9-20/h3-5,8-9,21H,2,6-7,10-19H2,1H3,(H2,25,26)
|
|||
InChIKey |
AHNMVVBJGPOWFW-UHFFFAOYSA-N
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Dopamine D2 receptor (D2R) | Target Info | Inhibitor | [1] |
Dopamine D3 receptor (D3R) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Dopaminergic synapse | ||||
Rap1 signaling pathway | ||||
cAMP signaling pathway | ||||
Gap junction | ||||
Parkinson's disease | ||||
Cocaine addiction | ||||
Alcoholism | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Dopamine receptor mediated signaling pathway | ||||
Nicotine pharmacodynamics pathway | ||||
Reactome | Dopamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
Nicotine Activity on Dopaminergic Neurons | ||||
GPCRs, Other | ||||
Hypothetical Network for Drug Addiction | ||||
Genes and (Common) Pathways Underlying Drug Addiction |
References | Top | |||
---|---|---|---|---|
REF 1 | Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.