Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09AVG
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| Former ID |
DNC008887
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| Drug Name |
5-amino-3-(N-methylpiperidin-4-yl)-1H-indole
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| Synonyms |
3-(1-methyl-4-piperidyl)indole-5-ylamine; CHEMBL521235; 3-(1-methylpiperidin-4-yl)-1h-indol-5-amine; 5-amino-3-(N-methylpiperidin-4-yl)-1H-indole; SCHEMBL427406; CTK6I2276; CKBJZDHVHHKARV-UHFFFAOYSA-N; BDBM50271135; AKOS024098950; 182564-38-1; 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole; 3-(1-Methyl-4-piperidinyl)-5-amino-1H-indole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H19N3
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| Canonical SMILES |
CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)N
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| InChI |
1S/C14H19N3/c1-17-6-4-10(5-7-17)13-9-16-14-3-2-11(15)8-12(13)14/h2-3,8-10,16H,4-7,15H2,1H3
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| InChIKey |
CKBJZDHVHHKARV-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1B receptor (HTR1B) | Target Info | Inhibitor | [1] |
| 5-HT 1D receptor (HTR1D) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-pip... J Med Chem. 2008 Jun 26;51(12):3609-16. | |||
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