Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09WCE
|
|||
| Former ID |
DIB006068
|
|||
| Drug Name |
IS-159
|
|||
| Synonyms |
133790-13-3; 2-(3-(2-aminoethyl)-1h-indol-5-yloxy)acetyl-l-tyrosyl-glycinamide; 2-[3-(2-aminoethyl)-1h-indol-5-yloxy]acetyl-l-tyrosyl-glycinamide; SCHEMBL6905927; AC1L52G2; CTK4B8797; Glycinamide,N-[[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]-L-tyrosyl- (9CI); AKOS030608101
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Migraine [ICD-11: 8A80; ICD-10: G43, G43.9; ICD-9: 346] | Discontinued in Phase 2 | [1] | |
| Company |
Immunotech SA
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C23H27N5O5
|
|||
| Canonical SMILES |
CC(=O)NC(CC1=C(C=C(C=C1)O)OC2=CC3=C(C=C2)NC=C3CCN)C(=O)NCC(=O)N
|
|||
| InChI |
1S/C23H27N5O5/c1-13(29)28-20(23(32)27-12-22(25)31)8-14-2-3-16(30)9-21(14)33-17-4-5-19-18(10-17)15(6-7-24)11-26-19/h2-5,9-11,20,26,30H,6-8,12,24H2,1H3,(H2,25,31)(H,27,32)(H,28,29)/t20-/m0/s1
|
|||
| InChIKey |
AUJLCXYDDFMYCQ-FQEVSTJZSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1B receptor (HTR1B) | Target Info | Modulator | [2] |
| 5-HT 1D receptor (HTR1D) | Target Info | Modulator | [2] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005786) | |||
| REF 2 | Pronounced effect of caprylocaproyl macrogolglycerides on nasal absorption of IS-159, a peptide serotonin 1B/1D-receptor agonist. Clin Pharmacol Ther. 2000 Aug;68(2):114-21. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.