Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D2CU
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Former ID |
DNC013625
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Drug Name |
(R)-(-)-2-Methyl-apomorphine hydrochloride
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Synonyms |
CHEMBL507567
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C18H19NO2
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Canonical SMILES |
CC1=CC2=C3C(CC4=C(C3=C1)C(=C(C=C4)O)O)N(CC2)C
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InChI |
1S/C18H19NO2/c1-10-7-12-5-6-19(2)14-9-11-3-4-15(20)18(21)17(11)13(8-10)16(12)14/h3-4,7-8,14,20-21H,5-6,9H2,1-2H3/t14-/m1/s1
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InChIKey |
QRJZCXSRTBCYIW-CQSZACIVSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Dopamine D2 receptor (D2R) | Target Info | Inhibitor | [1] |
Dopamine D3 receptor (D3R) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Rap1 signaling pathway | |||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Gap junction | ||||
Dopaminergic synapse | ||||
Parkinson's disease | ||||
Cocaine addiction | ||||
Alcoholism | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Dopamine receptor mediated signaling pathway | ||||
Nicotine pharmacodynamics pathway | ||||
Reactome | Dopamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Hypothetical Network for Drug Addiction | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
Genes and (Common) Pathways Underlying Drug Addiction | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
Nicotine Activity on Dopaminergic Neurons | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines. Bioorg Med Chem. 2008 Apr 1;16(7):3773-9. |
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