Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D5GD
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| Former ID |
DIB013065
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| Drug Name |
Flumazenil
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| Synonyms |
flumazenil; 78755-81-4; Anexate; Flumazepil; Romazicon; Lanexat; Mazicon; Ro 15-1788; Flumazenilum; Flumazenilo; Flumazenilum [Latin]; Flumazenilo [Spanish]; Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate; [11C]flumazenil; Ro 151788; Flumazenil (Ro 15-1788); Ro-15-1788; UNII-40P7XK9392; C15H14FN3O3; CHEMBL407; Ro15-1788; BRN 4763661; MLS000028850; Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; CHEBI:5103; OFBIFZUFASYYRE-UHFFFAOYSA-N; FlumUP TD; Flumazenil (transdermal patch formulation); Flumazenil (transdermal patch formulation), Coeruleus
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| Drug Type |
Small molecular drug
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| Indication | Benzodiazepine overdose [ICD-11: PC91] | Approved | [1], [2] | |
| Company |
Coeruleus Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H14FN3O3
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| Canonical SMILES |
CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
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| InChI |
1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
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| InChIKey |
OFBIFZUFASYYRE-UHFFFAOYSA-N
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| CAS Number |
CAS 78755-81-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10027, 5337218, 7847762, 7849653, 7979237, 8152147, 11111184, 11114035, 11532958, 12013048, 14849666, 17405069, 22391550, 24278437, 26719655, 26752172, 26752173, 29222508, 46386776, 46487948, 46507438, 47216937, 47216938, 47662473, 48035311, 48110620, 48416023, 49835190, 49978813, 50104818, 50104819, 50139275, 53777612, 56422177, 56464700, 56464701, 57321761, 58106963, 79129620, 80953768, 81065484, 85231047, 85788338, 90341071, 92303871, 92308307, 92308711, 92714603, 93166924, 99233261
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| ChEBI ID |
CHEBI:5103
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| ADReCS Drug ID | BADD_D00919 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-2 (GABRA2) | Target Info | Modulator (allosteric modulator) | [3] |
| GABA(A) receptor alpha-3 (GABRA3) | Target Info | Modulator (allosteric modulator) | [4] | |
| GABA(A) receptor alpha-5 (GABRA5) | Target Info | Modulator (allosteric modulator) | [5] | |
| GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator (allosteric modulator) | [6] | |
| Translocator protein (TSPO) | Target Info | Antagonist | [7] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| HTLV-I infection | ||||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| Iron uptake and transport | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4192). | |||
| REF 2 | ClinicalTrials.gov (NCT00997087) A Randomized, Double-Blind, Placebo-Controlled Trial of Flumazenil for the Treatment of Obsessive Compulsive Disorder. U.S. National Institutes of Health. | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). | |||
| REF 5 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). | |||
| REF 6 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). | |||
| REF 7 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879). | |||
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