Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0E9VU
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| Former ID |
DNC012645
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| Drug Name |
LEVONORDEFRIN
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| Synonyms |
levonordefrin; Corbadrine; Neo-Cobefrin; Nordefrin; 829-74-3; Corbadrinum; Corbadrina; alpha-Methylnoradrenaline; Corbadrinum [INN-Latin]; Corbadrina [INN-Spanish]; L-alpha-Methylnoradrenaline; Levonordefrin [USP]; Nordefrin, (-)-; UNII-V008L6478D; CHEBI:10304; 4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol; Corbadrine (INN); Corbadrine [INN]; Levonordefrin (USP); V008L6478D; CAS-829-74-3; DSSTox_RID_81553; DSSTox_CID_26349
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H13NO3
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| Canonical SMILES |
CC(C(C1=CC(=C(C=C1)O)O)O)N
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| InChI |
1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1
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| InChIKey |
GEFQWZLICWMTKF-CDUCUWFYSA-N
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| CAS Number |
CAS 829-74-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
13932, 7849447, 8149401, 10255593, 11111073, 11112447, 11335490, 11360729, 11364536, 11367098, 11369660, 11371540, 11373602, 11377822, 11461701, 11484746, 11488871, 11490296, 11491847, 11495456, 15947283, 24277784, 26611796, 26679431, 46238888, 47216686, 47365101, 47885314, 48110365, 48334396, 48334397, 48479897, 49699157, 50065272, 50100443, 50100444, 57350546, 57654107, 79290449, 92124111, 92307503, 99301403, 99443259, 103190505, 103938162, 113454748, 121363335, 124550756, 124637940, 124882389
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| ChEBI ID |
CHEBI:10304
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor alpha-1A (ADRA1A) | Target Info | Inhibitor | [2] |
| Adrenergic receptor alpha-1B (ADRA1B) | Target Info | Inhibitor | [2] | |
| Adrenergic receptor alpha-1D (ADRA1D) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Adrenergic signaling in cardiomyocytes | ||||
| Vascular smooth muscle contraction | ||||
| Salivary secretion | ||||
| AMPK signaling pathway | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
| Pathway Interaction Database | LPA receptor mediated events | |||
| Reactome | Adrenoceptors | |||
| G alpha (q) signalling events | ||||
| G alpha (12/13) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| Calcium Regulation in the Cardiac Cell | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| Vitamin D Receptor Pathway | ||||
| AMPK Signaling | ||||
| Endothelin Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 508). | |||
| REF 2 | Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. | |||
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