Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H6KD
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Former ID |
DIB018154
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Drug Name |
[125I]GTI
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Synonyms |
serotonin-5-O-carboxymethyl-glycyl-(125I)tyrosinamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C23H26IN5O5
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Canonical SMILES |
C1=CC(=C(C=C1CC(C(=O)N)NC(=O)CNC(=O)COC2=CC3=C(C=C2)NC=C3CCN)I)O
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InChI |
1S/C23H26IN5O5/c24-17-7-13(1-4-20(17)30)8-19(23(26)33)29-21(31)11-28-22(32)12-34-15-2-3-18-16(9-15)14(5-6-25)10-27-18/h1-4,7,9-10,19,27,30H,5-6,8,11-12,25H2,(H2,26,33)(H,28,32)(H,29,31)/t19-/m0/s1/i24-2
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InChIKey |
JVQSCVCNDUJMMW-BYWNROPASA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | 5-HT 1B receptor (HTR1B) | Target Info | Agonist | [2] |
5-HT 1D receptor (HTR1D) | Target Info | Agonist | [2] | |
KEGG Pathway | cAMP signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Serotonergic synapse | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
5HT1 type receptor mediated signaling pathway | ||||
Reactome | Serotonin receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Direct visualization of serotonin1D receptors in the human brain using a new iodinated radioligand. Brain Res Mol Brain Res. 1992 Mar;13(1-2):175-8. | |||
REF 2 | Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1993 Jun;347(6):569-82. |
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