Drug Information
Drug General Information | Top | |||
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Drug ID |
D0L8OJ
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Former ID |
DNC010483
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Drug Name |
Alstiphyllanine D
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Synonyms |
Alstiphyllanine D; CHEMBL540945
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C33H38N2O9
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Canonical SMILES |
CC=C1CN2C3CC1C(C45C3(N(C6=C4C=C(C=C6)OC)C)OC2C5)(COC(=O)C7=CC(=C(C(=C7)OC)OC)OC)C(=O)OC
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InChI |
1S/C33H38N2O9/c1-8-18-16-35-26-14-21(18)31(30(37)42-7,17-43-29(36)19-11-24(39-4)28(41-6)25(12-19)40-5)32-15-27(35)44-33(26,32)34(2)23-10-9-20(38-3)13-22(23)32/h8-13,21,26-27H,14-17H2,1-7H3/b18-8-/t21-,26-,27-,31-,32-,33-/m0/s1
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InChIKey |
JIGZBLWURVFVNC-MPYFAWNJSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | SLC5A2 messenger RNA (SLC5A2 mRNA) | Target Info | Inhibitor | [1] |
Sodium/glucose cotransporter 1 (SGLT1) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Carbohydrate digestion and absorption | |||
Bile secretion | ||||
Mineral absorption | ||||
Pathwhiz Pathway | Lactose Degradation | |||
Trehalose Degradation | ||||
Reactome | Hexose transport | |||
Na+-dependent glucose transporters | ||||
Inositol transporters | ||||
WikiPathways | NRF2 pathway | |||
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
Metabolism of carbohydrates |
References | Top | |||
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REF 1 | Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. |
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