Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0MU4A
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| Former ID |
DIB020976
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| Drug Name |
spiroxatrine
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| Synonyms |
spiroxamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C22H25N3O3
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| Canonical SMILES |
C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CC4COC5=CC=CC=C5O4
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| InChI |
1S/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26)
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| InChIKey |
JVGBTTIJPBFLTE-UHFFFAOYSA-N
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| CAS Number |
CAS 1054-88-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
239745, 511095, 5614464, 8153239, 11426887, 14902387, 17405698, 24278126, 26751807, 26751808, 29224323, 48035367, 48259474, 48334741, 50064107, 50104500, 50104501, 53778248, 57322687, 76693065, 85089532, 85209933, 85231214, 85788304, 90341505, 91746427, 92303168, 92308813, 103249514, 103931109, 104171234, 104308748, 121361869, 124750267, 124881358, 124881359, 124881360, 126408104, 128332426, 135028248, 135651066, 135697853, 137010278, 137263948, 138809382, 142936465, 144203811, 162022505, 162090868, 163138086
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| ChEBI ID |
CHEBI:91845
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 53). | |||
| REF 2 | Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. | |||
| REF 3 | [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):17-24. | |||
| REF 4 | Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes. Jpn J Pharmacol. 2001 Jun;86(2):189-95. | |||
| REF 5 | The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors. J Pharmacol Exp Ther. 1994 Dec;271(3):1558-65. | |||
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