Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N7UE
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Former ID |
DNC003845
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Drug Name |
Imidazolidin-2-ylidene-quinoxalin-6-yl-amine
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Synonyms |
91147-43-2; CHEMBL49395; Brimonidine impurity II; 6-Quinoxalinamine, N-(4,5-dihydro-1H-imidazol-2-yl)-; SCHEMBL679239; N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine; SCHEMBL12860178; ZINC14042; CTK3I1267; DTXSID00436663; MolPort-039-240-453; N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-QUINOXALINAMINE; BDBM50213029; N-quinoxalin-6-ylimidazolidin-2-imine; AKOS030240596
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C11H11N5
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Canonical SMILES |
C1CN=C(N1)NC2=CC3=NC=CN=C3C=C2
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InChI |
1S/C11H11N5/c1-2-9-10(13-4-3-12-9)7-8(1)16-11-14-5-6-15-11/h1-4,7H,5-6H2,(H2,14,15,16)
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InChIKey |
PVKUNRLEOHFACD-UHFFFAOYSA-N
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CAS Number |
CAS 91147-43-2
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Adrenergic receptor alpha-1A (ADRA1A) | Target Info | Inhibitor | [1] |
Adrenergic receptor alpha-1B (ADRA1B) | Target Info | Inhibitor | [1] | |
Adrenergic receptor alpha-1D (ADRA1D) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Calcium signaling pathway | |||
cGMP-PKG signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Adrenergic signaling in cardiomyocytes | ||||
Vascular smooth muscle contraction | ||||
Salivary secretion | ||||
AMPK signaling pathway | ||||
NetPath Pathway | IL2 Signaling Pathway | |||
Panther Pathway | Alpha adrenergic receptor signaling pathway | |||
Pathway Interaction Database | LPA receptor mediated events | |||
Reactome | Adrenoceptors | |||
G alpha (q) signalling events | ||||
G alpha (12/13) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
Calcium Regulation in the Cardiac Cell | ||||
GPCRs, Class A Rhodopsin-like | ||||
Vitamin D Receptor Pathway | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
AMPK Signaling | ||||
Endothelin Pathways | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). |
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