Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O3GF
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| Former ID |
DIB018225
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| Drug Name |
[3H]8-OH-DPAT
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| Synonyms |
8-OH-Dpat; 78950-78-4; 8-HYDROXY-2-(DI-n-PROPYLAMINO)TETRALIN; 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; 8-Hydroxy-DPAT; CHEMBL56; Ro-31-8220 in solution; CHEBI:73364; 1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-; S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT; (+/-)-8-HYDROXY-2-DIPROPYL-AMINOTETRALIN; [3H]-8-OH-DPAT; (+/-)-8-Hydroxy-DPAT hydrobromide; [3H]8-OH-DPAT; (+-)-8-OH-DPAT; S(-)-8-OH-DPAT HBr; S(-)-8-Hydroxy-DPAT hydrobromide; dl-8-Hydroxy-2-(dipropylamino)tetralin; GTPL7; 8OH-DPAT
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C16H25NO
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| Canonical SMILES |
CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
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| InChI |
1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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| InChIKey |
ASXGJMSKWNBENU-UHFFFAOYSA-N
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| CAS Number |
CAS 78950-78-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4548205, 7978612, 8151037, 14798544, 24263030, 24439565, 26751756, 47217012, 47515552, 47662525, 47810997, 48334740, 49689465, 49689466, 49996002, 50104448, 50104716, 53787713, 57320820, 76860501, 85208931, 85787801, 90341547, 103167491, 103806993, 103857988, 104297104, 117429498, 117617246, 124749825, 124880271, 124880272, 125702543, 125822395, 127454624, 135014291, 135649864, 135651130, 137005647, 140448617, 162914574, 163426000, 163882658, 179236036, 179425877, 184561482, 204360699, 223818122, 226812125, 241138490
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| ChEBI ID |
CHEBI:73364
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Agonist | [2] |
| 5-HT 1B receptor (HTR1B) | Target Info | Agonist | [3] | |
| 5-HT 1D receptor (HTR1D) | Target Info | Agonist | [3] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| SIDS Susceptibility Pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 31). | |||
| REF 2 | Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. J Med Chem. 2000 Nov 30;43(24):4701-10. | |||
| REF 3 | Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jun;359(6):447-53. | |||
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