Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S7WZ
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| Former ID |
DNC003652
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| Drug Name |
(-)-3-(1-Propyl-piperidin-3-yl)-benzonitrile
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| Synonyms |
3-(1-Propyl-3-piperidinyl)benzonitrile; 150336-90-6; 3-(1-propylpiperidin-3-yl)benzonitrile; CHEMBL107492; Benzonitrile,3-(1-propyl-3-piperidinyl)-; DS121 Cpd; 3-(3-Cyanophenyl)-N-n-propylpiperidine; AC1L1JNG; AC1Q4RGX; ACMC-1C3WE; SCHEMBL872942; CTK4C6605; BDBM50041960; 3-(1-Propylpiperidine-3-yl)benzonitrile; 3-(1-Propyl-piperidin-3-yl)-benzonitrile; (+)-3-(1-Propyl-piperidin-3-yl)-benzonitrile; L007862; Benzonitrile, 3-(1-propyl-3-piperidinyl)-, (+-)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H20N2
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| Canonical SMILES |
CCCN1CCCC(C1)C2=CC=CC(=C2)C#N
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| InChI |
1S/C15H20N2/c1-2-8-17-9-4-7-15(12-17)14-6-3-5-13(10-14)11-16/h3,5-6,10,15H,2,4,7-9,12H2,1H3
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| InChIKey |
GQRIAOUUYRIMLH-UHFFFAOYSA-N
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| CAS Number |
CAS 150336-90-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine D2 receptor (D2R) | Target Info | Inhibitor | [1] |
| Dopamine D3 receptor (D3R) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Dopaminergic synapse | ||||
| Rap1 signaling pathway | ||||
| cAMP signaling pathway | ||||
| Gap junction | ||||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Nicotine pharmacodynamics pathway | ||||
| Reactome | Dopamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| GPCRs, Other | ||||
| Hypothetical Network for Drug Addiction | ||||
| Genes and (Common) Pathways Underlying Drug Addiction | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists. J Med Chem. 1993 Oct 15;36(21):3188-96. | |||
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