Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0UO9T
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| Former ID |
DIB004758
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| Drug Name |
VR-147
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| Synonyms |
Migraine therapeutic, Vectura; Migraine therapy, Vectura; Triptan (inhaled, migraine), Vectura
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| Indication | Migraine [ICD-11: 8A80; ICD-10: G43, G43.9; ICD-9: 346] | Terminated | [1] | |
| Company |
Vectura Group plc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1B receptor (HTR1B) | Target Info | Modulator | [2], [3] |
| 5-HT 1D receptor (HTR1D) | Target Info | Modulator | [2], [3] | |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023937) | |||
| REF 2 | US patent application no. 2010,0112,050, Dosage form for insertion into the mouth. | |||
| REF 3 | Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75. | |||
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