Drug Information
Drug General Information | Top | |||
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Drug ID |
DD5VO3
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Drug Name |
TAK-906
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Synonyms |
Trazpiroben; UNII-FH87H57Q4Y; FH87H57Q4Y; triazaspiro[4.5]decan-3-yl]methyl}benzoic acid; 1352993-39-5; 3-{[1-cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8-; Trazpiroben [INN]; Trazpiroben [USAN]; SCHEMBL318454; WHO 11123; (3-((1-Cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8 triazaspiro(4.5) decan-3-yl)methyl)benzoic acid; 3-[[1-cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8-triazaspiro[4.5]decan-3-yl]methyl]benzoic acid; Benzoic acid, 3-((1-cyclohexyl-4-oxo-8-(4-oxo-4-phenylbutyl)-1,3,8-triazaspiro(4.5)dec-3-yl)methyl)-
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Drug Type |
Small molecular drug
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Indication | Diabetic gastroparesis [ICD-11: DA41.00] | Phase 2 | [1] | |
Company |
Takeda
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Structure |
Download2D MOL |
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Formula |
C31H39N3O4
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Canonical SMILES |
C1CCC(CC1)N2CN(C(=O)C23CCN(CC3)CCCC(=O)C4=CC=CC=C4)CC5=CC(=CC=C5)C(=O)O
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InChI |
1S/C31H39N3O4/c35-28(25-10-3-1-4-11-25)15-8-18-32-19-16-31(17-20-32)30(38)33(23-34(31)27-13-5-2-6-14-27)22-24-9-7-12-26(21-24)29(36)37/h1,3-4,7,9-12,21,27H,2,5-6,8,13-20,22-23H2,(H,36,37)
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InChIKey |
BDXJYAAYLZTLEK-UHFFFAOYSA-N
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CAS Number |
CAS 1352993-39-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Dopamine D2 receptor (D2R) | Target Info | Inhibitor | [2] |
Dopamine D3 receptor (D3R) | Target Info | Inhibitor | [2] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Dopaminergic synapse | ||||
Rap1 signaling pathway | ||||
cAMP signaling pathway | ||||
Gap junction | ||||
Parkinson's disease | ||||
Cocaine addiction | ||||
Alcoholism | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Dopamine receptor mediated signaling pathway | ||||
Nicotine pharmacodynamics pathway | ||||
Reactome | Dopamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
Nicotine Activity on Dopaminergic Neurons | ||||
GPCRs, Other | ||||
Hypothetical Network for Drug Addiction | ||||
Genes and (Common) Pathways Underlying Drug Addiction |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT03544229) A Study to Evaluate the Efficacy and Safety of TAK-906 in Adult Participants With Symptomatic Idiopathic or Diabetic Gastroparesis. U.S. National Institutes of Health. | |||
REF 2 | Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK-906), a Novel Selective D 2 /D 3 Receptor Antagonist: A Phase 1 Randomized, Placebo-Controlled Single- and Multiple-Dose Escalation Study in Healthy Participants. Clin Pharmacol Drug Dev. 2021 Jan 18. |
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