miRNA General Information
miRNA Mature ID hsa-miR-148b-3p
miRNA Stemloop AC MI0000811
miRNA Stemloop ID hsa-mir-148b
Sequence ucagugcaucacagaacuuugu
TTD Target(s) Regulated by This miRNA Gastrin/cholecystokinin type B receptor (CCKBR) Successful Target Target Info [1]
Heat shock protein 90 alpha (HSP90A) Successful Target Target Info [2]
PI3-kinase alpha (PIK3CA) Successful Target Target Info [3]
Rho-associated protein kinase 1 (ROCK1) Successful Target Target Info [3]
Mixed lineage kinase 1 (MAP3K9) Clinical trial Target Target Info [4]
DNA [cytosine-5]-methyltransferase 1 (DNMT1) Clinical trial Target Target Info [5]
DNA [cytosine-5]-methyltransferase 3B (DNMT3B) Clinical trial Target Target Info [6]
Integrin alpha-5 (ITGA5) Clinical trial Target Target Info [3]
GTPase NRas (NRAS) Clinical trial Target Target Info [3]
Macrophage colony-stimulating factor 1 (CSF1) Clinical trial Target Target Info [3]
Activin receptor-like kinase 2 (ALK-2) Clinical trial Target Target Info [7]
NADPH oxidase 2 (CYBB) Literature-reported Target Target Info [8]
Activated leukocyte cell adhesionmolecule (ALCAM) Clinical trial Target Target Info [9]
HepG2 glucose transporter (SLC2A1) Preclinical Target Target Info [10]
DNA mismatch repair protein Mlh1 (MLH1) Literature-reported Target Target Info [11]
Protein(s) Regulated by This miRNA 5'-AMP-activated protein kinase subunit beta-1 Regulated Protein [12]
HLA class I histocompatibility antigen, alpha chain G Regulated Protein [13]
Phosphatidylinositol 3-kinase regulatory subunit gamma Regulated Protein [14]
Proto-oncogene Wnt-1 Regulated Protein [15]
References
REF 1 Altered expression of MiR-148a and MiR-152 in gastrointestinal cancers and its clinical significance. J Gastrointest Surg. 2010 Jul;14(7):1170-9.
REF 2 Down-regulation of hsa-miR-148b inhibits vascular smooth muscle cells proliferation and migration by directly targeting HSP90 in atherosclerosis. Am J Transl Res. 2017 Feb 15;9(2):629-637.
REF 3 miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1. FASEB J. 2013 Mar;27(3):1223-35.
REF 4 In-depth analysis of the interaction of HIV-1 with cellular microRNA biogenesis and effector mechanisms. MBio. 2013 Apr 16;4(2):e000193.
REF 5 MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes. Hepatology. 2010 Mar;51(3):881-90.
REF 6 MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15805-10.
REF 7 The role of the 3'UTR region in the regulation of the ACVR1/Alk-2 gene expression. PLoS One. 2012;7(12):e50958.
REF 8 High-throughput screening identifies microRNAs that target Nox2 and improve function after acute myocardial infarction. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H1002-H1012.
REF 9 miR-214 coordinates melanoma progression by upregulating ALCAM through TFAP2 and miR-148b downmodulation. Cancer Res. 2013 Jul 1;73(13):4098-111.
REF 10 miR-148b inhibits glycolysis in gastric cancer through targeting SLC2A1. Cancer Med. 2017 Jun;6(6):1301-1310.
REF 11 miRNA-148b regulates radioresistance in non-small lung cancer cells via regulation of MutL homologue 1. Biosci Rep. 2016 Jun 30;36(3). pii: e00354.
REF 12 miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPK1.Mol Cancer Ther. 2013 Jan;12(1):83-93.
REF 13 Allele-specific targeting of microRNAs to HLA-G and risk of asthma.Am J Hum Genet. 2007 Oct;81(4):829-34.
REF 14 Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal cancer.Oncogene. 2015 Feb 12;34(7):912-21.
REF 15 Restoration of BRG1 inhibits proliferation and metastasis of lung cancer by regulating tumor suppressor miR-148b.Onco Targets Ther. 2015 Dec 2;8:3603-12.

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