miRNA General Information
miRNA Mature ID hsa-miR-376c-3p
miRNA Stemloop AC MI0000776
miRNA Stemloop ID hsa-mir-376c
Sequence aacauagaggaaauuccacgu
TTD Target(s) Regulated by This miRNA Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [1]
Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [2]
TGF-beta receptor type I (TGFBR1) Clinical trial Target Target Info [3]
Transforming growth factor alpha (TGFA) Clinical trial Target Target Info [4]
Liver receptor homolog-1 (NR5A2) Literature-reported Target Target Info [5]
Polycomb complex protein BMI-1 (BMI1) Clinical trial Target Target Info [6]
Runt-related transcription factor 2 (RUNX2) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA Activin receptor type-1C Regulated Protein [8]
UDP-glucuronosyltransferase 2B15 Regulated Protein [9]
UDP-glucuronosyltransferase 2B17 Regulated Protein [9]
REF 1 Silencing of a large microRNA cluster on human chromosome 14q32 in melanoma: biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor. Mol Cancer. 2012 Jul 2;11:44.
REF 2 hsa-miR-376c-3p Regulates Gastric Tumor Growth Both In Vitro and In Vivo. Biomed Res Int. 2016;2016:9604257.
REF 3 MicroRNA-376c impairs transforming growth factor- and nodal signaling to promote trophoblast cell proliferation and invasion. Hypertension. 2013 Apr;61(4):864-72.
REF 4 MicroRNA-376c inhibits cell proliferation and invasion in osteosarcoma by targeting to transforming growth factor-alpha. DNA Cell Biol. 2013 Jun;32(6):302-9.
REF 5 MicroRNA-376c suppresses non-small-cell lung cancer cell growth and invasion by targeting LRH-1-mediated Wnt signaling pathway. Biochem Biophys Res Commun. 2016 May 13;473(4):980-986.
REF 6 miR-376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1. Int J Exp Pathol. 2016 Jun;97(3):257-65.
REF 7 Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2016 Dec 15;76(24):7140-7150.
REF 8 MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance.J Cell Sci. 2011 Feb 1;124(Pt 3):359-68.
REF 9 Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer.J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):85-93.

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