miRNA General Information
miRNA Mature ID hsa-miR-433-3p
miRNA Stemloop AC MI0001723
miRNA Stemloop ID hsa-mir-433
Sequence aucaugaugggcuccucggugu
TTD Target(s) Regulated by This miRNA Proto-oncogene c-Met (MET) Successful Target Target Info [1]
cAMP-dependent chloride channel (CFTR) Successful Target Target Info [2]
Histone deacetylase 6 (HDAC6) Clinical trial Target Target Info [3]
Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Target Info [4]
Thymidylate synthase (TYMS) Clinical trial Target Target Info [5]
Cyclic AMP-responsive element-binding protein (CREB1) Literature-reported Target Target Info [1]
Runt-related transcription factor 2 (RUNX2) Literature-reported Target Target Info [6]
Protein(s) Regulated by This miRNA Antizyme inhibitor 1 Regulated Protein [7]
Fibroblast growth factor 20 Regulated Protein [8]
Guanylate-binding protein 2 Regulated Protein [9]
REF 1 c-Met and CREB1 are involved in miR-433-mediated inhibition of the epithelial-mesenchymal transition in bladder cancer by regulating Akt/GSK-3/Snail signaling. Cell Death Dis. 2016 Feb 4;7:e2088.
REF 2 Gene mutation in microRNA target sites of CFTR gene: a novel pathogenetic mechanism in cystic fibrosis PLoS One. 2013;8(3):e60448.
REF 3 A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia. Hum Mol Genet. 2010 May 15;19(10):2015-27.
REF 4 MicroRNA-433 Inhibits the Proliferation and Migration of HUVECs and Neurons by Targeting Hypoxia-Inducible Factor 1 Alpha. J Mol Neurosci. 2017 Feb;61(2):135-143.
REF 5 MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells. BMC Cancer. 2013 Aug 2;13:369.
REF 6 MiR-433 mediates ERR-suppressed osteoblast differentiation via direct targeting to Runx2 mRNA in C3H10T1/2 cells. Life Sci. 2013 Mar 21;92(10):562-8.
REF 7 The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-/Smad3-Azin1 pathway.Kidney Int. 2013 Dec;84(6):1129-44.
REF 8 Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.Am J Hum Genet. 2008 Feb;82(2):283-9.
REF 9 miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation.Leukemia. 2013 Feb;27(2):344-52.

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