miRNA General Information
miRNA Mature ID hsa-miR-7-1-3p
miRNA Stemloop AC MI0000263
miRNA Stemloop ID hsa-mir-7-1
Sequence caacaaaucacagucugccaua
TTD Target(s) Regulated by This miRNA Epidermal growth factor receptor (EGFR) Successful Target Target Info [1]
Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [1]
Proto-oncogene c-RAF (c-RAF) Clinical trial Target Target Info [1]
Inward rectifier potassium channel Kir2.1 (KCNJ2) Literature-reported Target Target Info [2]
References
REF 1 miR-7 reverses the resistance to BRAFi in melanoma by targeting EGFR/IGF-1R/CRAF and inhibiting the MAPK and PI3K/AKT signaling pathways. Oncotarget. 2016 Aug 16;7(33):53558-53570.
REF 2 Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway. Mol Cancer. 2015 Mar 12;14:59.

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