miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-7-1-3p | ||||
miRNA Stemloop AC | MI0000263 | ||||
miRNA Stemloop ID | hsa-mir-7-1 | ||||
Sequence | caacaaaucacagucugccaua | ||||
TTD Target(s) Regulated by This miRNA | Epidermal growth factor receptor (EGFR) | Successful Target | Target Info | [1] | |
Insulin-like growth factor I receptor (IGF1R) | Successful Target | Target Info | [1] | ||
Proto-oncogene c-RAF (c-RAF) | Clinical trial Target | Target Info | [1] | ||
Inward rectifier potassium channel Kir2.1 (KCNJ2) | Literature-reported Target | Target Info | [2] | ||
References | |||||
REF 1 | miR-7 reverses the resistance to BRAFi in melanoma by targeting EGFR/IGF-1R/CRAF and inhibiting the MAPK and PI3K/AKT signaling pathways. Oncotarget. 2016 Aug 16;7(33):53558-53570. | ||||
REF 2 | Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway. Mol Cancer. 2015 Mar 12;14:59. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.