Protein-Protein Interaction Details
Protein General Information | Top | ||||
---|---|---|---|---|---|
Full Name | 14-3-3 protein sigma (SFN) | ||||
UniProt ID | 1433S_HUMAN | ||||
Gene Name | SFN | ||||
Gene ID | 2810 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
Serine/threonine-protein kinase B-raf (BRAF) | Target Info | PPI Info | [2] | ||
Interacting Clinical trial Target(s) | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Target Info | PPI Info | [3] | |
Cellular tumor antigen p53 (TP53) | Target Info | PPI Info | [4] | ||
Proto-oncogene c-RAF (c-RAF) | Target Info | PPI Info | [5] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
REF 2 | Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Oncotarget. 2016 May 3;7(18):26628-52. | ||||
REF 3 | Roles for negative cell regulator 14-3-3sigma in control of MDM2 activities. Oncogene. 2007 Nov 15;26(52):7355-62. | ||||
REF 4 | Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways. Neoplasia. 2002 Mar-Apr;4(2):171-80. | ||||
REF 5 | Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat Cell Biol. 2005 Aug;7(8):837-43. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.