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| Protein General Information |
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| Full Name |
PPAR-gamma coactivator 1-alpha (PPARGC1A)
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| UniProt ID |
PRGC1_HUMAN
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| Gene Name |
PPARGC1A
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| Gene ID |
10891
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| Interacting TTD Target Information |
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| Interacting Successful Target(s) |
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) |
Target Info
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PPI Info
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[1] |
| Interacting Literature-reported Target(s) |
Pregnane X receptor (NR1I2) |
Target Info
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PPI Info
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[2] |
| Hepatocyte nuclear factor 4-alpha (HNF4A) |
Target Info
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PPI Info
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[3] |
| References |
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| REF 1 |
Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma. FEBS Lett. 2009 Sep 3;583(17):2720-6.
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| REF 2 |
Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepat... J Biol Chem. 2004 Oct 22;279(43):45139-47.
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| REF 3 |
Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c. Mol Endocrinol. 2007 Nov;21(11):2698-712.
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