Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01777 | Target Info | |||
| Target Name | Adrenergic receptor alpha-2C (ADRA2C) | ||||
| Synonyms |
Subtype C4; Alpha-2CAR; Alpha-2C adrenoreceptor; Alpha-2C adrenoceptor; Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptor subtype C4; ADRA2RL2; ADRA2L2
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| Target Type | Successful Target | ||||
| Gene Name | ADRA2C | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[[1-[(2-Methylphenyl)methyl]imidazol-2-yl]methyl]propan-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3588911; BDBM50097713; AKOS011502945
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| Activity |
EC50 = 147910.84 nM
|
[1] | |||
| Non Binders of This Target (in total, 11 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(3-Bromobenzyl)-1H-imidazole
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Investigative | Compound Info | ||
| Synonyms |
1-(3-Bromobenzyl)-1H-imidazole; 72459-47-3; 1-(3-bromobenzyl)imidazole; CHEMBL598391; 1H-Imidazole,1-[(3-bromophenyl)methyl]-; 1-[(3-bromophenyl)methyl]imidazole; SCHEMBL1848631; CTK5D6138; [(3-bromophenyl)methyl]imidazole; DTXSID00436926; BGYZLOIBJCHCTI-UHFFFAOYSA-N; MolPort-000-143-256; SBB098740; ZINC12370275; BDBM50307216; AKOS013124377; RP05747; KB-63888; 1-[(3-bromophenyl)methyl]-1H-imidazole; AJ-61784; DB-074567; ST24037191; Y9919; FT-0708606; 1-(3-bromobenzyl)-1H-imidazole, AldrichCPR; J-503102; Z1532751877
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| Activity |
EC50 > 501187.23 nM
|
[1] | |||
| Compound Name |
alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
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Investigative | Compound Info | ||
| Synonyms |
1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol; 1-(2,4-Dichlorophenyl)-2-(1-imidazolyl)ethanol; 1-(2,4-dichlorophenyl)-2-imidazol-1-ylethanol; 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol; CHEMBL1327; MFCD00044708; alpha-(2,4-Dichlorophenyl)-(1H)-imidazole-1-ethanol; 1-(2,4-DICHLORO-PHENYL)-2-IMIDAZOL-1-YL-ETHANOL; (+/-)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol; 1-(2,4-dichlorophenyl)-2-imidazolylethan-1-ol; EINECS 246-042-5; BRN 0617090; (1RS)-1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol; MLS000056514; T 824; a-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol; R 14821; 1H-Imidazole-1-ethanol, alpha-(2,4-dichlorophenyl)-; PubChem8377; Benzyl alcohol, 2,4-dichloro-alpha-(1-imidazolylmethyl)-; N-(beta-(2,4-Dichlorophenyl)-beta-hydroxyethyl)imidazole; UK 11147; ACMC-1CDPF; Sertaconazole Impurity A; EC 246-042-5; Econazole Related Compound A; 1H-Imidazole-1-ethanol, ?-(2,4-dichlorophenyl)-; Imidazole-1-ethanol, alpha-(2,4-dichlorophenyl)-; (1-Formyl-cyclopropyl)-NHBoc; IMI035; SCHEMBL4817509; 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanol; DTXSID3074737; CTK8B1283; 1-(2-(2,4-Dichlorophenyl)-2-hydroxyethyl)-1H-imidazole; HMS2166D10; HMS3315K04; ACT02031; BCP11459; EBD38978; KS-00000G7R; ANW-25339; BDBM50051838; SBB063966; STL452904; AKOS000121602; AKOS016842478; MCULE-3897692254; PS-3676; AC-26453; AK-86456; SC-02796; SMR000066401; SY002118; AB0012118; DB-046362; C3252; D3629; FT-0605479; ST50308226; A18508; K-6509; 155D428; 1-(2,4-dichloro-phenyl)-2-(1-imidazolyl) ethanol; 1H-Imidazole-1-ethanol,; A-(2,4-dichlorophenyl)-; W-107348; 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)-ethanol; 1-[2-(2,4-Dichlorophenyl)-2-hydroxyethyl]imidazole; Q27275605; Z56969300; 2,4-dichloro-alpha-[(1-imidazolyl)methyl]benzyl alcohol; 1-(2,4-dichlorophenyl)-2-(1h-imidazole-1-yl)-1-ethanol; 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethanol, AldrichCPR; 1-(2,4-dichlorophenyl)-1-hydroxy-2-(imidazol-1-yl)-ethane; 1H-Imidazole-1-ethanol, alpha-(2,4-dichlorophenyl)- (9CI)
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| Activity |
EC50 = 338844.16 nM
|
[1] | |||
| Compound Name |
N-[(2-Phenyl-1H-imidazol-5-yl)methyl]-1-pyridin-3-ylmethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3588905; BDBM50097719
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| Activity |
EC50 = 478630.09 nM
|
[1] | |||
| Compound Name |
Morpholine, 2-[(2-methoxyphenoxy)methyl]-
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Investigative | Compound Info | ||
| Synonyms |
2-[(2-methoxyphenoxy)methyl]morpholine; CHEMBL3588908; SCHEMBL6161190; BDBM50097716; AKOS013860438; 2-[(2-Methoxyphenoxy)methyl]-morpholine
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| Activity |
EC50 > 501187.23 nM
|
[1] | |||
| Compound Name |
3-Cyclopentyl-1-(1-thia-4,8-diazaspiro[4.5]decan-4-yl)propan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3588910; BDBM50097714
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| Activity |
EC50 > 501187.23 nM
|
[1] | |||
| Compound Name |
(2-Methylphenyl)(pyridin-4-ylmethyl)amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3588903; 2-methyl-N-(pyridin-4-ylmethyl)aniline; ALBB-020596; ZINC6663766; BDBM50097708; MFCD10455547; AKOS000241617
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| Activity |
EC50 > 501187.23 nM
|
[1] | |||
| Compound Name |
N-(3-Aminopropyl)-N-phenylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3588907; BDBM50097717; AKOS009144872
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| Activity |
EC50 > 501187.23 nM
|
[1] | |||
| Compound Name |
3-[2-(2-Aminoethyl)phenyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590203; BDBM50097712
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| Activity |
EC50 > 501187.23 nM
|
[1] | |||
| Compound Name |
1-[1-(3-Chlorophenyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-2-(ethylamino)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3588906; BDBM50097718
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| Activity |
EC50 > 501187.23 nM
|
[1] | |||
| Compound Name |
4-(4-Methylpiperazino)aniline
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Investigative | Compound Info | ||
| Synonyms |
4-(4-methylpiperazin-1-yl)aniline; 4-Methyl-1-(4-aminophenyl)piperazine; 4-(4-Methylpiperazin-1-yl)phenylamine; 4-(4-methyl-1-piperazinyl)aniline; 1-(4-Aminophenyl)-4-methylpiperazine; Benzenamine, 4-(4-methyl-1-piperazinyl)-; 4-(4-methylpiperazin-1-yl)benzenamine; 4-(4-Methyl-piperazin-1-yl)-phenylamine; MFCD00172703; CHEMBL341473; 4-(4-methyl-1-piperazinyl)phenylamine; F3308-1485; 4-(4-methylpiperazinyl)phenylamine; MLS000557450; 4-(4-Methyl-piperazino)aniline; PubChem9052; ACMC-1BUWK; Oprea1_401071; SCHEMBL56547; KSC498A9L; 4-(n-methylpiperazino)aniline; ARONIS24391; 4-(4-methylpiperazine)aniline; cid_737253; 4-(4-Methylpiperazino) aniline; CTK3J8095; 4-(N-methyl-piperizino) aniline; DTXSID90353214; HMS1728G09; HMS2410O15; ZINC166196; ACN-S003673; ACT04492; ALBB-022283; BCP24102; CS-M1029; KS-000048JN; 4-(4-methylpiperazine-1-yl)aniline; ANW-21941; BBL012742; BDBM50106345; CL1613; SBB015466; STK023618; WT1350; 1-methyl-4-(p-aminophenyl)piperazine; 4-(4-methylpiperazin-1-yl)-aniline; 4-(4-aminophenyl)-1-methylpiperazine; 4-(4-methyl-piperazin-1-yl)-aniline; AKOS000103038; 4-(4-methyl-1-piperazinyl)benzenamine; AC-2800; AS04456; LS40230; MCULE-8634922301; SDCCGMLS-0066262.P001; VP70240; 1-(4-aminophenyl) -4-methylpiperazine; 4-(4-methylpiperazin-1-yl)benzeneamine; KS-000009R7; 4-(4-methyl-1-piperazinyl)-benzenamine; 4-(4-methylpiperazin-1-yl)-phenylamine; 10G-420S; AK-21753; BP-10127; BR-21753; SC-01476; SMR000148366; SY002954; 4-(4-methyl-piperazin-1-yl) -phenylamine; AB0005328; DB-013712; AM20060329; BB 0216416; C2742; FT-0616653; M2154; ST45055154; V0667; [4-(4-methyl-piperazin-1-yl)-phenyl]-amine; 16153-81-4 4-(4-Methylpiperazino)aniline; C-5712; 153M814; AG-205/01890046; J-009838; J-513546
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| Activity |
EC50 > 501187.23 nM
|
[1] | |||
| Compound Name |
2-Amino-N-(2-phenoxyphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3588909; SCHEMBL18666145; BDBM50097715; AKOS000189270
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| Activity |
EC50 = 630957.34 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cell-based and virtual fragment screening for adrenergic alpha2C receptor agonists. Bioorg Med Chem. 2015 Jul 15;23(14):3991-9. | ||||
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