Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02551 | Target Info | |||
| Target Name | Dopamine D3 receptor (D3R) | ||||
| Synonyms |
D(3) dopamine receptor
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| Target Type | Successful Target | ||||
| Gene Name | DRD3 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 13 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dopamine
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Approved | Compound Info | ||
| Synonyms |
Dopamin; Dopamina; Dopaminum; Dophamine; Hydroxytyramin; Hydroxytyramine; Intropin; LDP; Oxytyramine; Revimine; ASL 279; IP 498; Dopamina [INN-Spanish]; Dopamine (INN); Dopamine [INN:BAN]; Dopaminum [INN-Latin]; L-DOPAMINE; M-Hydroxytyramine hydrochloride; Medopa (TN); Intropin [*hydrochloride*]; KW-3-060; Beta-(3,4-Dihydroxyphenyl)ethylamine hydrochloride; Dopamine (USAN)(*hydrochloride*); A-(3,4-Dihydroxyphenyl)-b-aminoethane; Alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane; Pyrocatechol, 4-(2-aminoethyl)-(8CI); Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride; (3H)-Dopamine; 1,2-Benzenediol, 4-(2-aminoethyl)-(9CI); 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride; 1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium; 153C5321-5FEE-4B0B-8925-F388F0EEEBD1; 2-(3,4-dihydroxyphenyl)ethylamine; 2-benzenediol; 3,4-Dihydroxyphenethylamine hydrochloride; 3,4-Dihydroxyphenylethylamine; 3,4-dihydroxyphenethylamine; 3-Hydroxtyramine; 3-Hydroxytyramine; 3-Hydroxytyramine Hydrobromide; 3-Hydroxytyramine hydrochloride; 4-(2-Aminoethyl)-1; 4-(2-Aminoethyl)-1,2-benzenediol; 4-(2-Aminoethyl)-1,2-bezenediol; 4-(2-Aminoethyl)benzene-1,2-diol; 4-(2-Aminoethyl)catechol; 4-(2-Aminoethyl)pyrocatechol; 4-(2-Aminoethyl)pyrocatechol hydrochloride; 4-(2-aminoethyl)-pyrocatechol
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| Activity |
Ki ~ 80000 nM
|
[1] | |||
| Compound Name |
N-Pentan-2-yl-1H-indole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100358; BDBM50267202; AKOS005842959
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| Activity |
Ki ~ 50000 nM
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[2] | |||
| Compound Name |
(11R)-5-Methyl-6,11-dioxo-N-(2-thiophen-2-ylethyl)benzo[b][1,4]benzothiazepine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3234545; SCHEMBL17837157; BDBM50003075; NCGC00250207-01
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[4-(4-Fluorophenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL425064; BDBM50189836
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| Activity |
Ki = 60000 nM
|
[4] | |||
| Compound Name |
[4-(4-Chloro-phenyl)-piperazin-1-yl]-pyrazolo[1,5-a]pyridin-3-yl-methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL7441; BDBM50073807
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| Activity |
Ki = 61000 nM
|
[5] | |||
| Compound Name |
3-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-2,7-dimethylimidazo[1,2-c]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL561262; BDBM50295933
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| Activity |
Ki = 67000 nM
|
[6] | |||
| Compound Name |
(2S)-4-(1H-Benzimidazol-2-ylmethyl)-2-(2-phenylethyl)morpholine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3335536; BDBM50027077
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| Activity |
IC50 = 76400 nM
|
[7] | |||
| Compound Name |
3-[4-(4-Chlorophenyl)piperazinomethyl]-4-(hydroxymethyl)pyrazolo[1,5-a]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL160396; BDBM50109951; {3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[1,5-a]pyridin-4-yl}-methanol
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| Activity |
Ki ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(Propan-2-yl)-1H-indole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073520; N-Isopropyl-1H-indole-2-carboxamide; 1H-Indole-2-carboxamide, N-(1-methylethyl)-; ACMC-20m9h5; SCHEMBL13753384; CTK0G4080; DTXSID60546575; BDBM50267203; AKOS008953205; MCULE-2614608477; N-propan-2-yl-1H-indole-2-carboxamide
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Heptan-4-yl-1H-indole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064919; SCHEMBL702104; BDBM50267205
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| Activity |
Ki ~ 100000 nM
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[2] | |||
| Compound Name |
N-(Cyclopropylmethyl)-1H-indole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092619; SCHEMBL6885051; BDBM50267204; AKOS009156341; MCULE-8383290655
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| Activity |
Ki ~ 100000 nM
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[2] | |||
| Compound Name |
(4As,5R,10bR)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1224527; BDBM50325822; trans-(5R)-5-phenyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[h]isoquinoline-7,8-diol
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| Activity |
Ki = 130000 nM
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[9] | |||
| Compound Name |
1-(4-Fluorophenyl)-6-[3-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]propyl]-1,6-diazaspiro[3.3]heptane
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098399; BDBM50250800
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| Activity |
Ki = 181888 nM
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[10] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. J Med Chem. 2008 Nov 13;51(21):6829-38. | ||||
| REF 2 | Synthesis and Pharmacological Characterization of Novel trans-Cyclopropylmethyl-Linked Bivalent Ligands That Exhibit Selectivity and Allosteric Pharmacology at the Dopamine D 3 Receptor (D 3 R). J Med Chem. 2017 Feb 23;60(4):1478-1494. | ||||
| REF 3 | Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists. J Med Chem. 2014 Apr 24;57(8):3450-63. | ||||
| REF 4 | 2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist. J Med Chem. 2006 Jun 29;49(13):3938-47. | ||||
| REF 5 | Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps. Bioorg Med Chem Lett. 1999 Jan 4;9(1):97-102. | ||||
| REF 6 | Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases. Bioorg Med Chem. 2009 Jul 1;17(13):4448-58. | ||||
| REF 7 | Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity. ACS Med Chem Lett. 2014 Jul 9;5(9):1060-4. | ||||
| REF 8 | Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy. Bioorg Med Chem Lett. 2002 Feb 25;12(4):633-6. | ||||
| REF 9 | Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists. Bioorg Med Chem. 2010 Sep 15;18(18):6763-70. | ||||
| REF 10 | Highly Selective Dopamine D 3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores. J Med Chem. 2017 Dec 14;60(23):9905-9910. | ||||
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