Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07173 | Target Info | |||
| Target Name | Tropomyosin-related kinase A (TrkA) | ||||
| Synonyms |
gp140trk; Tyrosine kinase receptor A; Tyrosine kinase receptor; Trk-A; TRKA; TRK1-transforming tyrosine kinase protein; TRK1 transforming tyrosinekinase protein; TRK; P140-TrkA; Neurotrophic tyrosine kinase receptor type 1; NGF-trk receptor type A; MTC; High affinity nerve growth factor receptor
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|
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| Target Type | Successful Target | ||||
| Gene Name | NTRK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 46 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Amitriptyline
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|
Approved | Compound Info | ||
| Synonyms |
Adepress; Adepril; Amitril; Amitriprolidine; Amitriptilina; Amitriptylin; Amitriptylinum; Amitryptiline; Amitryptyline; Amytriptiline; Amytriptylin; Damilan; Damilen; Damitriptyline; Elanil; Elavil; Flavyl; Lantron; Laroxil; Laroxyl; Proheptadiene; Redomex; Sarotex; Seroten; Sylvemid; Triptanol; Triptilin; Triptisol; Tryptanol; Amitriptilina [Italian]; Amitriptylin [German]; MK 230; N 750; TP0; Amitriptilina [INN-Spanish]; Amitriptyline (INN); Amitriptyline [INN:BAN]; Amitriptylinum [INN-Latin]; Elavil (TN); Laroxyl (TN); Ro 4-1575; [3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-amine; 10,11-Dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene; 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-delta(5),gamma-propylamine; 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d]cycloheptene; 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)-N,N-dimethylpropylamin; 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine; 5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene; 5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene; 5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene; 5-(3-dimethylaminopropylidene)dibenzo[a,d][1,4]-cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene; 5-(gamma-Dimethylaminopropylidene)-5H-Dibenzo[a,d][1,4]cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene; 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo[a,d]10,11-dihydrocycloheptene; 5-(gamma-Dimethylaminopropylidine)-5H-dibenzo(a,d)(1,4)cycloheptadiene
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|
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| Activity |
IC50 = 60000 nM
|
[1] | |||
| Compound Name |
6-[3-[(5-Carbamoyl-2-phenylpyrazol-3-yl)carbamoyl]-4-chlorophenyl]pyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942722; SCHEMBL17249559; BDBM226383; US9328096, 76
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|
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
Benz[b]indeno[1,2-e]pyran-6,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629616; INDENO[2,1-B]CHROMENE-6,11-DIONE; Wrightiadione; ACMC-20n5dj; CTK0H6525; DTXSID70439666; BDBM50128509
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||||
| Activity |
IC50 = 55800 nM
|
[3] | |||
| Compound Name |
Chembl4216925
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17443081; BDBM50457844
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|
||||
| Activity |
IC50 = 61000 nM
|
[4] | |||
| Compound Name |
N-(Pyridin-2-ylmethyl)-2-thiophen-2-ylindole-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080705; BDBM50242499
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|
||||
| Activity |
IC50 = 64320 nM
|
[5] | |||
| Compound Name |
5,7-Dimethylindeno[2,1-b]quinoline-6,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629607; BDBM50128518
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|
||||
| Activity |
IC50 = 73300 nM
|
[3] | |||
| Compound Name |
Chembl4204606
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL16853591; BDBM50457845
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|
||||
| Activity |
IC50 = 74000 nM
|
[4] | |||
| Compound Name |
N-[2-(2-Thiophen-2-ylindol-1-yl)ethyl]pyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088575; BDBM50242455
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|
||||
| Activity |
IC50 = 74020 nM
|
[5] | |||
| Compound Name |
1-Tert-butyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-2-yl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318026; SCHEMBL1933008; BDBM50050848
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|
||||
| Activity |
IC50 = 80630 nM
|
[6] | |||
| Compound Name |
2-(2-Pyridin-3-ylindol-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075690; BDBM50242452
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|
||||
| Activity |
IC50 ~ 81010 nM
|
[5] | |||
| Compound Name |
N-[(1-Methylimidazol-2-yl)methyl]-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073036; BDBM50242480
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|
||||
| Activity |
IC50 ~ 81010 nM
|
[5] | |||
| Compound Name |
2-(2-Phenylpyrrolo[3,2-b]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103783; BDBM50242458
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|
||||
| Activity |
IC50 ~ 81010 nM
|
[5] | |||
| Compound Name |
N-(Pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)ethanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104935; BDBM50242444
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|
||||
| Activity |
IC50 ~ 81010 nM
|
[5] | |||
| Compound Name |
N-(2-Pyridin-2-ylethyl)-2-thiophen-2-ylindole-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073807; BDBM50242482
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|
||||
| Activity |
IC50 ~ 81010 nM
|
[5] | |||
| Compound Name |
N-Pyridin-2-yl-2-(2-thiophen-2-ylindol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097229; BDBM50242498
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|
||||
| Activity |
IC50 ~ 81010 nM
|
[5] | |||
| Compound Name |
N-[2-(2-Thiophen-2-ylindol-1-yl)ethyl]pyridine-2-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067321; BDBM50242469
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|
||||
| Activity |
IC50 ~ 81010 nM
|
[5] | |||
| Compound Name |
3-Chloro-5-methylindeno[2,1-b]quinoline-6,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629604; BDBM50128519
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|
||||
| Activity |
IC50 = 88500 nM
|
[3] | |||
| Compound Name |
2-(2-Phenylpyrrolo[2,3-b]pyridin-1-yl)-N-(pyridin-2-ylmethyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090227; BDBM50242490
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|
||||
| Activity |
IC50 = 99820 nM
|
[5] | |||
| Compound Name |
1-(4-Methoxyphenyl)-3-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781939
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(3-Methoxyphenyl)-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3782023
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-Phenyl-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780571
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781159
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-[7-(3,4-Dimethoxyphenyl)-1,5-naphthyridin-2-yl]-3-ethylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318024; SCHEMBL1932174; BDBM50050850
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-[1-(4-Chlorobenzyl)-1h-indol-3-yl]-n-(4-nitrophenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221633; BDBM50324796
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-(3-Methoxyphenyl)-3-(3-phenylpyrido[3,4-b]pyrazin-8-yl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780358
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780543
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-Tert-butyl-3-[7-(3,4-dimethoxyphenyl)-1,5-naphthyridin-2-yl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318025; SCHEMBL1932951; BDBM50050849
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-(3-Ethynylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780350
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-Ethyl-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780985
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-[[3-(1,3-Thiazol-2-yl)phenyl]methyl]-3-[4-(trifluoromethoxy)phenyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3298364; BDBM50022678
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(3-Methoxyphenyl)-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780768
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-(3-Phenylpyrido[3,4-b]pyrazin-8-yl)-3-prop-2-enylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781906
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-Phenyl-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781538
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-(5-Tert-butyl-1,2-oxazol-3-yl)-3-[3-(6-chloropyrazin-2-yl)oxyphenyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3596856; BDBM50498461
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185140; SCHEMBL21585709; BDBM50324797; 3-(1-(4-chlorobenzyl)-1H-indol-3-yl)-N-(pyridin-4-yl)propanamide; 3-[1-(4-Chloro-benzyl)-1H-indol-3-yl]-N-pyridin-4-yl-propionamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781584
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(2-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781543
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-Benzyl-3-[7-(1-methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318029; SCHEMBL1933048; BDBM50050853
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-(3-Chloro-4-fluorophenyl)-3-phenylpyrido[3,4-b]pyrazin-8-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3780151
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-(4-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3781566
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-[7-(1-Methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]-3-phenylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318028; SCHEMBL1932302; BDBM50050854
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
1-Ethyl-3-[7-(4-methoxyphenyl)-1,5-naphthyridin-2-yl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3318023; SCHEMBL1932961; BDBM50050851
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
1-(3-Tert-butylphenyl)-3-[3-(6-chloropyrazin-2-yl)oxyphenyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3596857; BDBM50498451
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
5-Methyl-3-(trifluoromethyl)indeno[2,1-b]quinoline-6,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629606; BDBM50128521
Click to Show/Hide
|
||||
| Activity |
IC50 = 117000 nM
|
[3] | |||
| Compound Name |
7-Hydroxy-5-methylindeno[2,1-b]quinoline-6,11-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629609; BDBM50128516
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|
||||
| Activity |
IC50 = 141000 nM
|
[3] | |||
| Compound Name |
1H-Benz(de)isoquinoline-1,3(2H)-dione, 2-((2-hydroxyethyl)amino)-5-nitro-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ALE-0540; UNII-1R1L47BXMJ; 1R1L47BXMJ; CHEMBL440470; Oprea1_821712; SCHEMBL3857057; 2-(2-hydroxyethylamino)-5-nitrobenzo[de]isoquinoline-1,3-dione; ZINC1903557; BDBM50111443; MCULE-3035531849; Q27252774; 2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquinoline-1,3-dione(ALE-0540)
Click to Show/Hide
|
||||
| Activity |
IC50 = 149000 nM
|
[11] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
10-Methoxy-5-methylindeno[2,3-b]quinoline-6,11-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629612; BDBM50128513
Click to Show/Hide
|
||||
| Activity |
IC50 = 209000 nM
|
[3] | |||
| Compound Name |
Chembl4217454
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17443064; BDBM50457846
Click to Show/Hide
|
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| Activity |
IC50 = 410000 nM
|
[4] | |||
| Compound Name |
2-[[1-Cyclopentyl-5-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyrazol-3-Yl]amino]pyridine-4-Carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629013; GTPL9989; SCHEMBL22137472; BDBM50128294; AKOS032960466; compound 11 [PMID: 26431428]; Q27455367; 2-(1-Cyclopentyl-5-(1-(oxetane-3-yl)-4-piperidinyl)-1H-pyrazole-3-ylamino)pyridine-4-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 464000 nM
|
[12] | |||
| Compound Name |
4-Methyl-N-[5-(7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl]pyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671380; SCHEMBL17745501; BDBM135017; US8846698, 499
Click to Show/Hide
|
||||
| Activity |
IC50 = 9800000000 nM
|
[13] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery. J Med Chem. 2015 Jan 22;58(2):767-77. | ||||
| REF 2 | US patent application no. 9328096B2, Tropomyosin-related kinase inhibitors | ||||
| REF 3 | Discovery of wrightiadione as a novel template for the TrkA kinase inhibitors. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5186-9. | ||||
| REF 4 | Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. J Med Chem. 2018 Aug 9;61(15):6779-6800. | ||||
| REF 5 | Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2695-2701. | ||||
| REF 6 | Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3748-52. | ||||
| REF 7 | Efficient synthesis of novel disubstituted pyrido[3,4-b]pyrazines for the design of protein kinase inhibitors. Medchemcomm. 2016;7:224-9. | ||||
| REF 8 | Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5203-6. | ||||
| REF 9 | Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain. J Med Chem. 2014 Jul 10;57(13):5800-16. | ||||
| REF 10 | Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies. Medchemcomm. 2014 Oct 1;5(10):1507-1514. | ||||
| REF 11 | Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. J Med Chem. 2017 Jan 12;60(1):66-88. | ||||
| REF 12 | Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 22;58(20):8182-99. | ||||
| REF 13 | US patent application no. 8846698B2, Pyrrolo[2,3-d]pyrimidine tropomysin-related kinase inhibitors | ||||
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