Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T08391 | Target Info | |||
| Target Name | Janus kinase 2 (JAK-2) | ||||
| Synonyms |
Tyrosine-protein kinase JAK2
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| Target Type | Successful Target | ||||
| Gene Name | JAK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 53 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Niclosamide
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|
Approved | Compound Info | ||
| Synonyms |
niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Oxindole 94
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Investigative | Compound Info | ||
| Synonyms |
SB 202190; 152121-30-7; SB202190; SB-202190; FHPI; SB202190 (FHPI); UNII-PVX798P8GI; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole; CHEBI:79090; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; PVX798P8GI; SB 202190, Immobilized; C20H14FN3O; Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-; 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol; 4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Chloro-N-(3-quinoxalin-2-ylphenyl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463405; CHEMBL3645538; BDBM107121; US8592415, 5; 4-chloro-N-[3-(quinoxalin-2-yl)phenyl]butanamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(Dimethylamino)-N-(3-quinoxalin-2-ylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463296; CHEMBL3645535; BDBM107118; US8592415, 2; N2,N2-dimethyl-N1-(3-quinoxalin-2-ylphenyl)glycinamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-Chloro-N-(3-quinoxalin-2-ylphenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463291; CHEMBL3645548; BDBM107134; US8592415, 19; 3-chloro-N-[3-(quinoxalin-2-yl)phenyl]propanamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(3-Quinoxalin-2-ylphenyl)-2-(1,2,4-triazol-1-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1464125; CHEMBL3645539; BDBM107123; US8592415, 7; N-[3-(quinoxalin-2-yl)phenyl]-2-(1H-1,2,4-triazol-1-yl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL104074; CHEMBL104466; RP-127963; 4-[(6,7-dimethoxyquinoxalin-2-yl)amino]cyclohexan-1-ol; SCHEMBL842647; SCHEMBL842648; SCHEMBL3393843; CTK0I9204; DTXSID30430871; Cyclohexanol, 4-[(6,7-dimethoxy-2-quinoxalinyl)amino]-, trans-; BDBM50132391; BDBM50132407; cis-4-(6, 7-Dimethoxyquinoxalin-2-ylamino)-cyclohexanol; cis-4-(6,7-Dimethoxyquinoxalin-2-ylamino)-cyclohexanol; 4-((R)-6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol; Trans-4-((6,7-dimethoxyquinoxalin-2-yl)amino)cyclohexanol; trans-4-(6,7-dimethoxy-quinoxalin-2-ylamino)-cyclohexanol; 2-(4alpha-Hydroxycyclohexane-1alpha-ylamino)-6,7-dimethoxyquinoxaline; 2-(4beta-Hydroxycyclohexane-1alpha-ylamino)-6,7-dimethoxyquinoxaline
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Chembl4285755
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-(4-Methylpiperazin-1-yl)-N-(3-quinoxalin-2-ylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1464066; CHEMBL3645546; BDBM107132; US8592415, 17; 2-(4-methylpiperazin-1-yl)-N-[3-(quinoxalin-2-yl)phenyl]acetamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-Morpholino-N-(3-(quinoxalin-2-yl)phenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463453; CHEMBL3645549; BDBM107135; US8592415, 20; 2-morpholin-4-yl-N-(3-quinoxalin-2-ylphenyl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Chembl4289149
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|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-Chloro-N-(3-quinoxalin-2-ylphenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1463360; CHEMBL3645550; BDBM107136; US8592415, 21; 2-chloro-N-(3-(quinoxalin-2-yl)phenyl)propanamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(3-Quinoxalin-2-ylphenyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
MLS000537362; SCHEMBL1462316; CHEMBL1446198; BDBM107122; HMS1599D07; HMS2400O23; ZINC555918; AKOS003653098; MCULE-9745117709; N-[3-(2-quinoxalinyl)phenyl]propanamide; SMR000143800; N-[3-(quinoxalin-2-yl)phenyl]propionamide; ST45104659; US8592415, 6; SR-01000287574; SR-01000287574-1
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-(4-Methoxyphenyl)-N'-[3-(2-quinoxalinyl)phenyl]urea
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Investigative | Compound Info | ||
| Synonyms |
1-(4-methoxyphenyl)-3-[3-(quinoxalin-2-yl)phenyl]urea; 1-(4-methoxyphenyl)-3-(3-quinoxalin-2-ylphenyl)urea; SCHEMBL1463272; CHEMBL3645542; KS-00001ZVQ; BDBM107126; ZINC1399313; AKOS005099783; MCULE-4650809137; US8592415, 10; 7T-0007
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[3-(2-Quinoxalinyl)phenyl]-2-thiophenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
n-[3-(quinoxalin-2-yl)phenyl]thiophene-2-sulfonamide; N-(3-quinoxalin-2-ylphenyl)thiophene-2-sulfonamide; SCHEMBL1462283; CHEMBL3645543; KS-00001ZVS; BDBM107128; ZINC1399318; AKOS005099846; MCULE-1175160761; US8592415, 13; 7T-0014
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| Activity |
IC50 = 55500 nM
|
[3] | |||
| Compound Name |
Chembl4279618
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17551676
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| Activity |
IC50 = 98000 nM
|
[6] | |||
| Compound Name |
COc1cc(F)c(C)cc1-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=CCN(C)C)c1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948029; SCHEMBL16176432; SCHEMBL16176434; BDBM195902; US9206188, 138
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
CN(C)CC=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(C)c2c1
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906494; SCHEMBL16176693; SCHEMBL16176694; BDBM195907; US9206188, 152; (E)-4-(dimethylamino)-N-(3-(3-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)but-2-enamide
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Disodium;2-[4-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120985
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Sodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314273
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-[5-(4-Fluorophenyl)-3-methyl-2-(2H-triazol-4-yl)imidazol-4-yl]pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120960; BDBM50045572
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(4-Fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314271; SCHEMBL6217129; BDBM50045555
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Tert-butyl-3-[[5-cyano-2-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885292; BDBM50208591
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2R,3R,4R,5S,6R)-3-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]-6-(hydroxymethyl)oxane-2,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314270; BDBM50045576
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4228653
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50460794
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]ethanol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120963; BDBM50045575
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Disodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314275
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-[4-(4-Fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazol-2-yl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314285; BDBM50045570
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
COc1cc(F)c(C)cc1-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3920230; SCHEMBL16176455; BDBM195903; US9206188, 140
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
7-Ethynyl-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314272; BDBM50045556
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(E)-N-[3-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]-4-(dimethylamino)but-2-enamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3921295; SCHEMBL16176593; SCHEMBL16176594; BDBM195908; US9206188, 153
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-[2-(4-Ethynylphenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-methylsulfanylpyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314286; BDBM50045571
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(4-Fluorophenyl)-3-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]imidazo[1,2-a]pyrimidin-7-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120970; SCHEMBL13823117; BDBM50045580
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-[4-(1,1-Dioxothiomorpholin-4-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3360840; SCHEMBL2635678; BDBM50031737; MFCD31382011
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-[5-(4-Fluorophenyl)-2-[1-[(3S,4S)-3-fluoropiperidin-4-yl]triazol-4-yl]-3-methylimidazol-4-yl]pyridine;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120986
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(3-(2-Oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)acrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934456; SCHEMBL16176494; BDBM195906; US9206188, 150; N-[3-(2-oxo-1,3-dihydropyrrolo[2,3-b]pyridin-5-yl)phenyl]prop-2-enamide
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120983; BDBM50045574
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Cc1cccc(-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)c1F
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3919033; SCHEMBL16176564; BDBM195905; US9206188, 148
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355482; BDBM50043416; ZINC17334508; AKOS008571954; Z31474376
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-[2-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-5-(4-fluorophenyl)-3-methylimidazol-4-yl]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120969; BDBM50045578
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
7-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3314274; BDBM50045558
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098682; BDBM50242512
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(E)-4-(Dimethylamino)-N-[3-[3-(2-fluoro-3-methylphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]but-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943435; SCHEMBL16176305; SCHEMBL16176307; BDBM195904; US9206188, 145
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(E)-N-[3-[3-(3,5-Difluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-4-fluorophenyl]-4-(dimethylamino)but-2-enamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925725; SCHEMBL16176656; SCHEMBL16176657; BDBM195901; US9206188, 133
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3120995; BDBM50045573
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[1-(4-Chlorobenzyl)-1h-indol-3-yl]-n-(4-nitrophenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221633; BDBM50324796
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|
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| Activity |
IC50 = 106700 nM
|
[13] | |||
| Compound Name |
1-[(1-{2-[(3-Chloro-1,2-Dimethyl-1h-Indol-5-Yl)amino]pyrimidin-4-Yl}-3-Methyl-1h-Pyrazol-4-Yl)methyl]azetidin-3-Ol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622956; SCHEMBL15133954; BDBM138200; US8871778, 141; Q27467492
Click to Show/Hide
|
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| Activity |
IC50 = 111900 nM
|
[14] | |||
| Compound Name |
(3R)-1-[[1-[2-(3,5-Dimethylanilino)pyrimidin-4-yl]-4-methylpyrrol-3-yl]methyl]pyrrolidin-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622924; SCHEMBL1326183; BDBM50124705
Click to Show/Hide
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| Activity |
IC50 = 115300 nM
|
[14] | |||
| Compound Name |
6-Bromo-1H-indazol-3-amine
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Investigative | Compound Info | ||
| Synonyms |
3-Amino-6-bromo-1H-indazole; 6-BROMO-1H-INDAZOL-3-YLAMINE; 1H-INDAZOL-3-AMINE, 6-BROMO-; MFCD05665872; CHEMBL501406; 6-BROMO-1H-INDAZOLE-3-AMINE; 3-Amino-6-bromo-1H-indazole, 95%; PubChem17937; ACMC-209jef; SCHEMBL424831; 6-Bromo-3-amino-1H-indazole; 6-Bromo-2h-indazol-3-ylamine; 1H-Indazol-3-amine,6-bromo-; 6-bromo-1H-indazole-3-ylamine; SCHEMBL18340819; CTK4I3153; DTXSID40383026; ALBB-028238; BCP26665; KS-00000A2U; ZINC3883310; ANW-29413; BBL030369; BDBM50254987; SBB052082; SC1841; STL250230; AKOS000779557; CS-W003246; LS40886; MCULE-9201895154; PB26168; QC-9106; 6-Bromo-1H-indazol-3-amine, AldrichCPR; AC-23301; AK-28301; BC004311; BR-28301; SC-45063; SY006752; AB0002478; DB-026380; A6772; AM20040422; BB 0259389; FT-0677999; A-2900; 827B776; 10Y-0701; J-518297
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| Activity |
IC50 = 131000 nM
|
[15] | |||
| Compound Name |
N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185140; SCHEMBL21585709; BDBM50324797; 3-(1-(4-chlorobenzyl)-1H-indol-3-yl)-N-(pyridin-4-yl)propanamide; 3-[1-(4-Chloro-benzyl)-1H-indol-3-yl]-N-pyridin-4-yl-propionamide
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| Activity |
IC50 = 133600 nM
|
[13] | |||
| Compound Name |
1-[(3-Methyl-1-{2-[(1,2,3-Trimethyl-1h-Indol-5-Yl)amino]pyrimidin-4-Yl}-1h-Pyrazol-4-Yl)methyl]azetidin-3-Ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622958; SCHEMBL15310875; BDBM50124868; Q27454824
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| Activity |
IC50 = 138200 nM
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[14] | |||
| Compound Name |
6-Phenyl-1H-indazol-3-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL446576; 1H-Indazol-3-amine, 6-phenyl-; SCHEMBL3361070; KS-00002YOD; ZINC8733638; BDBM50254864; MFCD08281822; AKOS015991834; MCULE-1165818473; DA-16428; FT-0727345; 10Y-0725
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| Activity |
IC50 = 145300 nM
|
[15] | |||
| Compound Name |
(3R)-1-[[1-[2-[(3-Chloro-1,2-dimethylindol-5-yl)amino]pyrimidin-4-yl]-3-methylpyrazol-4-yl]methyl]pyrrolidin-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622957; SCHEMBL15134039; BDBM138210; US8871778, 189
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| Activity |
IC50 = 162400 nM
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[14] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
ISIS-CRP
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|
Phase 1 | Compound Info | ||
| Synonyms |
1-(Tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 172889-27-9; pp2; PP 2; 1-(tert-butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; AG 1879; 1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; PP2; 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; AG-1879; CHEMBL406845; CHEBI:78331; AK-60369; 1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine; 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; C15H16ClN5; 1qpe; 4few; PBBRWFOVCUAONR-UHFFFAOYSA-N; AG1879; PP 2 (AG 1879)
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| Activity |
IC50 > 50000000 nM
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[16] | |||
| Compound Name |
1-(2-Aminoethyl)-2-(4-piperidinyl)-1H-benzoimidazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3622826; BDBM50124147
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| Activity |
IC50 = 437300 nM
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[17] | |||
| Compound Name |
N-(6-(6,7-Dimethoxyquinolin-4-yloxy)-1-methyl-1H-indazol-3-yl)-3-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL462168; SCHEMBL4381571; BDBM50245420; N-[6-(6,7-dimethoxyquinolin-4-yl)oxy-1-methylindazol-3-yl]-3-(trifluoromethyl)benzamide; Benzamide, N-[6-[(6,7-dimethoxy-4-quinolinyl)oxy]-1-methyl-1H-indazol-3-yl]-3-(trifluoromethyl)-
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| Activity |
IC50 = 25000000 nM
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[18] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9. | ||||
| REF 2 | Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38alpha MAPK, CK1 and JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3412-8. | ||||
| REF 3 | US patent application no. 8592415B2, Selective kinase inhibitors | ||||
| REF 4 | Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 2: the synthesis and biological activities of RPR127963 an orally bioavailable inhibitor. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3097-100. | ||||
| REF 5 | Identification of imidazo[1,2- b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Medchemcomm. 2016 Dec 15;8(4):700-712. | ||||
| REF 6 | Design, synthesis and evaluation of ( R)-3-(7-(methyl(7 H-pyrrolo[2,3- d]pyrimidin-4-yl)amino)-5-azaspiro[2.4]heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor. Medchemcomm. 2018 Jan 15;9(3):477-489. | ||||
| REF 7 | US patent application no. 9206188B2, Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors | ||||
| REF 8 | Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors. Eur J Med Chem. 2016 Nov 29;124:896-905. | ||||
| REF 9 | Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90). Bioorg Med Chem Lett. 2018 May 1;28(8):1357-1362. | ||||
| REF 10 | Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634. J Med Chem. 2014 Nov 26;57(22):9323-42. | ||||
| REF 11 | Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. ACS Med Chem Lett. 2014 Aug 7;6(1):53-7 | ||||
| REF 12 | Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2708-2712. | ||||
| REF 13 | Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5203-6. | ||||
| REF 14 | Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4441-6. | ||||
| REF 15 | Fragment-based discovery of JAK-2 inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):279-82. | ||||
| REF 16 | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. | ||||
| REF 17 | Benzimidazole Derivatives as Potent JAK1-Selective Inhibitors. J Med Chem. 2015 Sep 24;58(18):7596-602. | ||||
| REF 18 | Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4844-8. | ||||
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