Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T08446 | Target Info | |||
| Target Name | Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) | ||||
| Synonyms |
Solute carrier family 6 member 12; Sodium- and chloride-dependent betaine transporter; BGT-1
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| Target Type | Literature-reported Target | ||||
| Gene Name | SLC6A12 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 21 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
GSK683699
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|
Phase 2 | Compound Info | ||
| Synonyms |
4-Aminobutanoic acid; 4-aminobutyric acid; GABA; gamma-aminobutyric acid; 1956/12/2; Piperidic acid; Piperidinic acid; Aminalon; Mielogen; Gammalon; Gaballon; butanoic acid, 4-amino-; Mielomade; Gammalone; Gamarex; Gammasol; Gammar; Reanal; Immu-G; gamma-amino-n-butyric acid; gamma-Aminobutanoic acid; Butyric acid, 4-amino-; Gamastan; Gammagee; Gamulin; 4-aminobutyrate; omega-Aminobutyric acid; gamma-Aminobutyric acid; 3-Carboxypropylamine; gamma-Aminobuttersaeure; 4-amino-butanoic acid; gamma-Amino butyric acid; GAMMA-AMINO-BUTANOIC ACID
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| Activity |
IC50 = 165958.69 nM
|
[1] | |||
| Compound Name |
SNAP-5114
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Investigative | Compound Info | ||
| Synonyms |
157604-55-2; (S)-SNAP-5114; (S)-SNAP 5114; CHEMBL75035; (S)-1-[2-[TRIS(4-METHOXYPHENYL)METHOXY]ETHYL]-3-PIPERIDINECARBOXYLIC ACID; GTPL4677; SCHEMBL18187570; CTK0H0672; DTXSID40440224; MolPort-003-983-686; HMS3268E15; ZINC3995954; MFCD06411702; BN0494; BDBM50039246; AKOS024456666; NCGC00025217-02; B6792; SR-01000597587; (S)-SNAP-5114, > SR-01000597587-1; (S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid; (3S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic
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| Activity |
IC50 = 71700 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072046; BDBM50250320
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(2-cyanophenyl)methyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091409; BDBM50250285
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(4-cyanophenyl)methyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097791; BDBM50250287
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-[1-(quinolin-2-ylmethyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097124; BDBM50250321
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-2,4-dichlorobenzamide
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Investigative | Compound Info | ||
| Synonyms |
BPDBA; CHEMBL1882801; N-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamide; CBMicro_018714; Cambridge id 5349520; Oprea1_510498; MLS001185535; REGID_for_CID_1069892; HMS2820D15; ZINC756543; CCG-6976; BDBM50250267; STK053506; AKOS001766690; MCULE-7422285654; SMR000502170; ST047807; BIM-0018815.P001; AB00082098-01; SR-01000519597; SR-01000519597-1; (2,4-dichlorophenyl)-N-[1-benzyl(4-piperidyl)]carboxamide
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| Activity |
IC50 = 58000 nM
|
[1] | |||
| Compound Name |
1-{2-[Bis-(4-chloro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL269439; BDBM50039242
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|
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| Activity |
IC50 = 88000 nM
|
[3] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-2,3-dimethoxybenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL123282; Benzamide, 2,3-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-; ACMC-20lvjh; CTK3G1860; DTXSID80536473; BDBM50007525; STK491510; ZINC13820638; AKOS003382241; CCG-300432; MCULE-7445608673; ST50942926; N-[1-Benzyl-4-piperidinyl]-2,3-dimethoxybenzamide; N-(1-Benzyl-piperidin-4-yl)-2,3-dimethoxy-benzamide; (2,3-dimethoxyphenyl)-N-[1-benzyl(4-piperidyl)]carboxamide
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|
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| Activity |
IC50 = 91000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(4-iodophenyl)methyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070660; BDBM50250288
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102978; BDBM50250284
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(E)-3-phenylprop-2-enyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071982; BDBM50250319
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl 4-[[4-[(2,4-dichlorobenzoyl)amino]piperidin-1-yl]methyl]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090080; BDBM50250289
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-4-fluorobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080696; CBMicro_022999; Cambridge id 5524786; Oprea1_465872; Oprea1_626089; SCHEMBL1425074; ZINC84471; CCG-9823; BDBM50250253; STK006992; AKOS000673109; MCULE-3904225512; ST029666; BIM-0022886.P001; N-(1-benzyl-4-piperidinyl)-4-fluorobenzamide; AB00087319-01; AG-690/11635812; SR-01000407328; SR-01000407328-1; Z32353707; (4-fluorophenyl)-N-[1-benzyl(4-piperidyl)]carboxamide
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-(1-phenacylpiperidin-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070193; BDBM50250265
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(R,E)-1-(4-(2-Fluorophenyl)-4-o-tolylbut-3-enyl)piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1641613; BDBM50334247
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(4-nitrophenyl)methyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069676; BDBM50250255
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-{2-[(4-Methoxy-phenyl)-di-p-tolyl-methoxy]-ethyl}-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310236; BDBM50039235
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|
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| Activity |
IC50 = 109000 nM
|
[3] | |||
| Compound Name |
1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL72499; BDBM50039238
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|
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| Activity |
IC50 = 151000 nM
|
[3] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-3-(trifluoromethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078727; BDBM50250272; STK491613; ZINC12820866; AKOS003382124; CCG-300437; MCULE-2073961827; NCGC00330960-01; AB01324863-02; AO-854/43461993; Z32353728; N-(1-benzyl-4-piperidinyl)-3-(trifluoromethyl)benzamide
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|
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| Activity |
IC50 = 169824.37 nM
|
[1] | |||
| Compound Name |
2-Ethoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1710951; N-(1-benzylpiperidin-4-yl)-2-ethoxybenzamide; MLS001179109; HMS2847J17; ZINC7039831; BDBM50250278; STK413823; AKOS003387340; CCG-300452; MCULE-7182820341; SMR000477296; ST50943613; N-(1-benzyl-4-piperidinyl)-2-ethoxybenzamide; Q27183433; (2-ethoxyphenyl)-N-[1-benzyl(4-piperidyl)]carboxamide
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|
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| Activity |
IC50 = 180000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 36 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Tiagabine
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|
Approved | Compound Info | ||
| Synonyms |
tiagabine; 115103-54-3; Gabitril; Tiagabinum; Tiagabina; (R)-Tiagabine; Tiagabinum [INN-Latin]; Tiagabina [INN-Spanish]; Tiagabine [INN:BAN]; Tiagabine [INN]; Abbott-70569; UNII-Z80I64HMNP; Tiagabine (INN); ABBOTT-70569-1; Gabitril (TN); CHEMBL1027; Z80I64HMNP; ABT-569; CHEBI:9586; NO-328; (-)-(R)-1-(4,4-Bis(3-methyl-2-thienyl)-3-butenyl)nipecotic acid; A-70569-1; (R)-1-(4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid; Gabatril; NO 329; Gabitril; NO-329; Tiagabina [INN-Spanish];Tiagabine (INN); N-(4,4-di(3-methylthien-2-yl)but-3-enyl)nipecotic acid; (3R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic acid; (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid; [3H]tiagabine
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| Activity |
IC50 = 1670000 nM
|
[3] | |||
| Compound Name |
CI-966
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|
Phase 1 | Compound Info | ||
| Synonyms |
1-[2-[Bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride
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| Activity |
IC50 = 300000 nM
|
[3] | |||
| Compound Name |
4-substituted 2,4-dioxobutanoic acids
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Investigative | Compound Info | ||
| Synonyms |
Guvacine; 1,2,5,6-tetrahydropyridine-3-carboxylic acid; 498-96-4; 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid; UNII-41538P325K; 1,2,5,6-Tetrahydronicotinic acid; CHEBI:5576; 1,2,3,6-tetrahydropyridine-5-carboxylic acid; 41538P325K; 1,2,5,6-Tetrahydro-pyridine-3-carboxylic acid; MLS000859975; SMR000326834; Spectrum_001426; Tocris-0234; SpecPlus_000808; Lopac-G-007; AC1Q5RCN; Spectrum2_001474; Spectrum4_001753; Spectrum3_001511; Spectrum5_000606; Biomol-NT_000253; C10149; AC1L1G5E; Lopac0_000571; BSPBio_003181; KBioSS_001906
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| Activity |
IC50 = 1870000 nM
|
[3] | |||
| Compound Name |
(R)-nipecotic acid
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Investigative | Compound Info | ||
| Synonyms |
(R)-piperidine-3-carboxylic acid; 25137-00-2; (R)-(-)-Nipecotic acid; (3R)-piperidine-3-carboxylic acid; (R)-(-)-3-Piperidinecarboxylic acid; (-)-nipecotic acid; (3R)-nipecotic acid; (3R)-(-)-piperidine-3-carboxylic acid; D(-)-Nipecotic acid; r-(-)-3-piperidinecarboxylic acid; 3-Piperidinecarboxylic acid, (R)-; (R)-hexahydronicotinic acid; (R)-(-)-piperidine-3-carboxylic acid; (-)-hexahydronicotinic acid; (3R)-hexahydronicotinic acid; CHEMBL77575; (r)-3-piperidinecarboxylic acid
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| Activity |
IC50 = 2310000 nM
|
[3] | |||
| Compound Name |
NIPECOTIC ACID
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Investigative | Compound Info | ||
| Synonyms |
Piperidine-3-carboxylic acid; 498-95-3; h-dl-nip-oh; EINECS 207-873-9; CHEMBL277498; dl-piperidine-3-carboxylic acid; 60252-41-7; CHEBI:116931; XJLSEXAGTJCILF-UHFFFAOYSA-N; MFCD00005992; SR-01000075612; Nipecotic; h-nip-oh; 3-carboxypiperidine; (y)-Nipecotic acid; ( inverted exclamation markA)-Nipecotic acid; PubChem6793; D-nipecotic acid-HCl; h-dl-pic(3)-oh; (RS)-nipecotic acid
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| Activity |
IC50 = 2370000 nM
|
[3] | |||
| Compound Name |
(S)-Piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
59045-82-8; (S)-(+)-Nipecotic acid; (3S)-piperidine-3-carboxylic acid; (S)-nipecotic acid; (3S)-nipecotic acid; (S)-(+)-3-Piperidinecarboxylic acid; (S)-hexahydronicotinic acid; L(+)-NIPECOTIC ACID; (3S)-hexahydronicotinic acid; CHEBI:222169; (3S)-3-piperidinecarboxylic acid; 3-Piperidinecarboxylic acid, (3S)-; (S)-(+)-PIPERIDINE-3-CARBOXYLIC ACID; UNII-2635N2PS4Q; (3S)-(+)-piperidine-3-carboxylic acid; L-PIPERIDINE-3-CARBOXYLIC ACID
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| Activity |
IC50 = 6410000 nM
|
[3] | |||
| Compound Name |
SKF89976A
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Investigative | Compound Info | ||
| Synonyms |
SKF-89976A; SKF 89976A
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| Activity |
IC50 = 7210000 nM
|
[5] | |||
| Compound Name |
1-{2-[(4-Methoxy-3-trifluoromethyl-phenyl)-phenyl-(3-trifluoromethyl-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77166; BDBM50039241
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|
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| Activity |
IC50 = 201000 nM
|
[3] | |||
| Compound Name |
1-[2-[Tris(4-methoxyphenyl)methoxy]ethyl]piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL432737; (S)-SNAP5114; 1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid; 1-(2-(Tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid; SCHEMBL16415738; SNAP 5114; BDBM50039234
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| Activity |
IC50 = 208000 nM
|
[3] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
N-(1-(Benzyl)-4-piperidyl)benzamide; CHEMBL1603838; N-[1-(BENZYL)-4-PIPERIDYL]BENZAMIDE; N1-(1-Benzyl-4-piperidyl)benzamide; EINECS 213-538-8; N-(1-Benzyl-piperidin-4-yl)-benzamide; (Indoramin Impurity)'; Maybridge1_006192; ChemDiv2_000250; Cambridge id 5357691; Oprea1_272991; Oprea1_804305; MLS001182250; SCHEMBL694949; 1-benzyl-4-benzamidopiperidine; 1-benzyl-4-benzamido-piperidine; CTK5H9110; HMS559B10; DTXSID00242701; HMS1369L08; HMS2880E21; ZINC247186; KS-000031BO; BDBM50250266; CCG-40855; STK007131; N-(1-Benzyl-4-piperidinyl)benzamide; AKOS000671616; MCULE-3265010155; N-(1-Benzyl-4-piperidinyl)benzamide #; NCGC00246644-01; 12N-312S; SMR000567875; N-[1-(phenylmethyl)piperidin-4-yl]benzamide; phenyl-N-[1-benzyl(4-piperidyl)]carboxamide; ST50449722; AB00082791-01; Benzamide, N-[1-(phenylmethyl)-4-piperidinyl]-; N-[1-(BENZYL)-PIPERIDIN-4-YL]BENZAMIDE; SR-01000630966-1; Z32353754
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| Activity |
IC50 = 290000 nM
|
[1] | |||
| Compound Name |
(3S)-8-Benzhydrylidene-1,2,3,4,6,7,9,9a-octahydroquinolizine-3-carboxylic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2093977
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|
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| Activity |
IC50 = 335000 nM
|
[5] | |||
| Compound Name |
1-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL78166; BDBM50039240
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|
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| Activity |
IC50 = 382000 nM
|
[3] | |||
| Compound Name |
1-(2-Tritylsulfanyl-ethyl)-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308528; BDBM50039244
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| Activity |
IC50 = 435000 nM
|
[3] | |||
| Compound Name |
(3R)-8-Benzhydrylidene-1,2,3,4,6,7,9,9a-octahydroquinolizine-3-carboxylic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2094024
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|
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| Activity |
IC50 = 436000 nM
|
[5] | |||
| Compound Name |
(R)-1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419823; NCGC00025217-01; Tocris-1561; BDBM50039248; J-009426; (R)-1-(2-(Tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid; (3R)-1-[2-[(4,4',4''-Trimethoxytrityl)oxy]ethyl]piperidine-3-carboxylic acid
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|
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| Activity |
IC50 = 630000 nM
|
[3] | |||
| Compound Name |
1-{2-[(4-Methoxy-phenyl)-diphenyl-methoxy]-ethyl}-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL77111; BDBM50039249
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|
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| Activity |
IC50 = 655000 nM
|
[3] | |||
| Compound Name |
(3S,8R)-8-Benzhydryl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine-3-carboxylic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2094022
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|
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| Activity |
IC50 = 809000 nM
|
[5] | |||
| Compound Name |
1-[2-(9-Phenyl-9H-xanthen-9-yloxy)-ethyl]-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74854; BDBM50039243
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|
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| Activity |
IC50 = 920000 nM
|
[3] | |||
| Compound Name |
2,4-Dichloro-N-{1-[(pyridin-2-yl)methyl]piperidin-4-yl}benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069761; BDBM50250317; ZINC48356032; AKOS034525333; CCG-300720; MCULE-2170841553; Z667591870
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|
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 2-[4-[(2,4-dichlorobenzoyl)amino]piperidin-1-yl]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075412; BDBM50250282
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|
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-[1-(pyridin-3-ylmethyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063054; BDBM50250318
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|
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-[1-(3-diethoxyphosphorylpropyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072002; BDBM50250283
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|
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-[1-(pyridin-4-ylmethyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079046; BDBM50250316
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|
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-(1-ethylpiperidin-4-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101561; BDBM50250275; STK484443; ZINC13325962; AKOS003397123; MCULE-5433262397; ST50879941; Z85145662; (2,4-dichlorophenyl)-N-(1-ethyl(4-piperidyl))carboxamide
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| Activity |
IC50 > 1000000 nM
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[1] | |||
| Compound Name |
2,4-Dichloro-N-(1-methylpiperidin-4-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072452; BDBM50250274; STK484800; ZINC13326354; AKOS003394651; MCULE-2479589844; ST50846723; N-(1-Methylpiperidine-4-yl)-2,4-dichlorobenzamide; benzamide, 2,4-dichloro-N-(1-methyl-4-piperidinyl)-; (2,4-dichlorophenyl)-N-(1-methyl(4-piperidyl))carboxamide
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-[1-(3-cyanopropyl)piperidin-4-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076258; BDBM50250281
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| Activity |
IC50 > 1000000 nM
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[1] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-2,6-dichloropyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060376; BDBM50250295
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-piperidin-4-ylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066152; BDBM50250302; ZINC37382809; AKOS009375943
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
2,4-Dichloro-N-(1-propylpiperidin-4-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075423; BDBM50250279; STK484461; ZINC13325985; AKOS003396540; MCULE-8663330192; ST50894261; Z90656452; (2,4-dichlorophenyl)-N-(1-propyl(4-piperidyl))carboxamide
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| Activity |
IC50 > 1000000 nM
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[1] | |||
| Compound Name |
2,4-Dichloro-N-(1-prop-2-ynylpiperidin-4-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077212; BDBM50250280
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| Activity |
IC50 > 1000000 nM
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[1] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-2-methylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089518; N-(1-Benzyl-piperidin-4-yl)-isobutyramide; N-(1-benzylpiperidin-4-yl)isobutyramide; N-(1-benzyl-4-piperidyl)-2-methyl-propanamide; Oprea1_472165; SCHEMBL3306841; CTK1B9881; DTXSID90364148; ZINC4551463; BDBM50250322; STK012158; AKOS003820004; MCULE-3952577164; Propanamide, 2-methyl-N-[1-(phenylmethyl)-4-piperidinyl]-
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| Activity |
IC50 > 1000000 nM
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[1] | |||
| Compound Name |
2-[4-[(2,4-Dichlorobenzoyl)amino]piperidin-1-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075865; BDBM50250254
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||||
| Activity |
IC50 > 1000000 nM
|
[1] | |||
| Compound Name |
1-{2-[Tris-(4-fluoro-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77423; BDBM50039253
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| Activity |
IC50 = 1270000 nM
|
[3] | |||
| Compound Name |
1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL405620; BDBM50039247
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| Activity |
IC50 = 2660000 nM
|
[3] | |||
| Compound Name |
(3R,8R)-8-Benzhydryl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine-3-carboxylic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2093978
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| Activity |
IC50 = 2900000 nM
|
[5] | |||
| Compound Name |
1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77626; SCHEMBL676997; 3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-butenyl)-, (R)-; CTK3G8883; ZINC3995837; (R)-SKF-89976A; BDBM50020891; (3R)-1-(4,4-diphenylbut-3-enyl)piperidine-3-carboxylic acid; (R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxylic acid
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| Activity |
IC50 = 7210000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/-Aminobutyric Acid Transporter 1 (BGT1). J Med Chem. 2017 Nov 9;60(21):8834-8846. | ||||
| REF 2 | Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor. ACS Med Chem Lett. 2014 Jun 16;5(8):889-93. | ||||
| REF 3 | Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3. J Med Chem. 1994 Jul 22;37(15):2334-42. | ||||
| REF 4 | Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors. Bioorg Med Chem Lett. 2011 Jan 1;21(1):602-5. | ||||
| REF 5 | On the bioactive conformation of the gaba uptake inhibitor SK&F 89976-A. Bioorg Med Chem Lett. 1996 Jul 9;6(13):1535-40. | ||||
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